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EPID 在立体定向肺部治疗风险管理中的体内剂量学作用。

The role of EPID in vivo dosimetry in the risk management of stereotactic lung treatments.

机构信息

S. C. Fisica Sanitaria, Firenze-Azienda Sanitaria USL Toscana Centro, Via dell'Antella 58, 50012, Bagno a Ripoli, Firenze, Italy.

International Center for Theoretical Physics, Strada Costiera, 11, 34151, Trieste, Italy.

出版信息

Strahlenther Onkol. 2023 Nov;199(11):992-999. doi: 10.1007/s00066-023-02081-x. Epub 2023 May 31.

Abstract

BACKGROUND AND OBJECTIVE

In this work we report our experience with the use of in vivo dosimetry (IVD) in the risk management of stereotactic lung treatments.

METHODS

A commercial software based on the electronic portal imaging device (EPID) signal was used to reconstruct the actual planning target volume (PTV) dose of stereotactic lung treatments. The study was designed in two phases: i) in the observational phase, the IVD results of 41 consecutive patients were reviewed and out-of-tolerance cases were studied for root cause analysis; ii) in the active phase, the IVD results of 52 patients were analyzed and corrective actions were taken when needed. Moreover, proactive preventions were further introduced to reduce the risk of future failures. The error occurrence rate was analyzed to evaluate the effectiveness of proactive actions.

RESULTS

A total of 330 fractions were analyzed. In the first phase, 13 errors were identified. In the active phase, 12 errors were detected, 5 of which needed corrective actions; in 4 patients the actions taken corrected the error. Several preventions and barriers were introduced to reduce the risk of future failures: the planning checklist was updated, the procedure for vacuum pillows was improved, and use of the respiratory compression belt was optimized. A decrease in the failure rate was observed, showing the effectiveness of procedural adjustment.

CONCLUSION

The use of IVD allowed the quality of lung stereotactic body radiation therapy (SBRT) treatments to be improved. Patient-specific and procedural corrective actions were successfully taken as part of risk management, leading to an overall improvement in the dosimetric accuracy.

摘要

背景与目的

本研究旨在报告我们在立体定向肺部治疗风险管理中使用体内剂量学(IVD)的经验。

方法

采用基于电子射野影像装置(EPID)信号的商业软件来重建立体定向肺部治疗的实际计划靶区(PTV)剂量。研究分两个阶段进行:i)在观察阶段,回顾了 41 例连续患者的 IVD 结果,并对超出公差的病例进行了根本原因分析;ii)在主动阶段,分析了 52 例患者的 IVD 结果,并在需要时采取了纠正措施。此外,还引入了主动预防措施,以降低未来失败的风险。通过分析误差发生率来评估主动措施的有效性。

结果

共分析了 330 个分次。在第一阶段,发现了 13 个误差。在主动阶段,检测到 12 个误差,其中 5 个需要采取纠正措施;在 4 名患者中,所采取的措施纠正了误差。为降低未来失败的风险,引入了多项预防和障碍措施:更新了计划检查表,改进了真空枕的使用流程,并优化了呼吸压缩带的使用。观察到失败率的降低,表明了程序调整的有效性。

结论

使用 IVD 提高了肺部立体定向体部放射治疗(SBRT)的治疗质量。作为风险管理的一部分,成功采取了患者特异性和程序纠正措施,从而提高了剂量学准确性的整体水平。

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