Odio C M, Faingezicht I, Salas J L, Guevara J, Mohs E, McCracken G H
Pediatr Infect Dis. 1986 Jul-Aug;5(4):402-7. doi: 10.1097/00006454-198607000-00005.
Eighty-five infants and children were prospectively randomized to receive cefotaxime or ampicillin and chloramphenicol for therapy of bacterial meningitis. The two therapy groups of patients were comparable as to sex, age, clinical status on admission, prior administration of antibiotics and etiology. Three infants (7%) died in each therapy group. Mean number of days of positive cerebrospinal fluid cultures, time to defervescence and duration of treatment and of hospital stay and complications developing during treatment were similar for the two treatment regimens. Median cerebrospinal fluid bactericidal titers against the patients' pathogens in cefotaxime-treated patients (1:64) were larger than those in patients who received conventional therapy (1:8). Mild to moderate motor sequelae were more frequent in those given conventional therapy at the time of discharge only, and not at 4 months or longer of follow-up. We conclude that cefotaxime has similar efficacy when compared with conventional therapy for the management of bacterial meningitis in pediatric patients.
85名婴幼儿被前瞻性随机分组，分别接受头孢噻肟或氨苄青霉素加氯霉素治疗细菌性脑膜炎。两个治疗组的患者在性别、年龄、入院时的临床状况、先前使用抗生素情况及病因方面具有可比性。每个治疗组有3名婴儿（7%）死亡。两种治疗方案在脑脊液培养阳性的平均天数、退热时间、治疗持续时间、住院时间以及治疗期间出现的并发症方面相似。头孢噻肟治疗患者针对其病原体的脑脊液杀菌效价中位数（1:64）高于接受传统治疗的患者（1:8）。仅在出院时，接受传统治疗的患者轻度至中度运动后遗症更为常见，而在4个月或更长时间的随访中则不然。我们得出结论，与传统治疗相比，头孢噻肟在治疗小儿细菌性脑膜炎方面具有相似的疗效。
