Mayhew T M, Jackson M R, Haas J D
Placenta. 1986 Mar-Apr;7(2):121-31. doi: 10.1016/s0143-4004(86)80003-0.
A combination of stereological and physicochemical data was used to estimate the oxygen-diffusing capacity of the human term placenta. The effects on this morphometric diffusing capacity of isolated changes in placental structure were investigated by permitting volumes, surface areas and harmonic mean diffusion distances to deviate from normal baseline (term) values. Diffusion performance could be monitored effectively by estimating only three structural quantities. The most influential variable was the harmonic mean thickness of the villous membrane followed by the surface areas of villi and of fetal capillaries. Blood space volumes and plasma diffusion distances had negligible effects on diffusing capacity. Conclusions are discussed in the context of published findings on changes in placental anatomy which occur during gestation, abnormal pregnancies and pregnancies at high altitude.
采用体视学和物理化学数据相结合的方法来估算足月人类胎盘的氧扩散能力。通过使体积、表面积和谐波平均扩散距离偏离正常基线（足月）值，研究胎盘结构的单独变化对这种形态测量扩散能力的影响。仅通过估算三个结构量就可以有效地监测扩散性能。最具影响力的变量是绒毛膜的谐波平均厚度，其次是绒毛和胎儿毛细血管的表面积。血腔体积和血浆扩散距离对扩散能力的影响可忽略不计。结合已发表的关于妊娠期、异常妊娠和高原妊娠期间胎盘解剖结构变化的研究结果对结论进行了讨论。
