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采用克隆文库方法检测戈登链球菌和痤疮丙酸杆菌，发现与纵隔淋巴结肿大相关的结节病。

Sarcoidosis Associated with Enlarged Mediastinal Lymph Nodes with the Detection of Streptococcus gordonii and Cutibacterium acnes Using a Clone Library Method.

机构信息

Division of Infection Control and Prevention, University of Occupational and Environmental Health, Japan.

Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan.

出版信息

Intern Med. 2024 Jan 15;63(2):299-304. doi: 10.2169/internalmedicine.1887-23. Epub 2023 May 31.

DOI:10.2169/internalmedicine.1887-23
PMID:37258161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10864086/
Abstract

A 77-year-old Japanese woman with mediastinal lymphadenopathy and uveitis was diagnosed with sarcoidosis. The bacterial flora in biopsied samples from mediastinal lymph nodes was analyzed using a clone library method with Sanger sequencing of the 16S rRNA gene, and Streptococcus gordonii (52 of 71 clones) and Cutibacterium acnes (19 of 71 clones) were detected. No previous study has conducted a bacterial floral analysis using the Sanger method for the mediastinal lymph node in sarcoidosis, making this case report the first to document the presence of S. gordonii and C. acnes in the mediastinal lymph node of a patient with sarcoidosis.

摘要

一位 77 岁的日本女性患有纵隔淋巴结病和葡萄膜炎，被诊断为结节病。使用 Sanger 测序法对 16S rRNA 基因进行克隆文库方法分析纵隔淋巴结活检样本中的细菌菌群，检测到链球菌戈登（71 个克隆中的 52 个）和痤疮丙酸杆菌（71 个克隆中的 19 个）。以前没有使用 Sanger 法对结节病纵隔淋巴结进行细菌菌群分析的研究，因此本病例报告首次记录了链球菌戈登和痤疮丙酸杆菌存在于结节病患者的纵隔淋巴结中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91f8/10864086/68237ec08aa5/1349-7235-63-0299-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91f8/10864086/dd8570b8ec5d/1349-7235-63-0299-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91f8/10864086/0b6de5f13049/1349-7235-63-0299-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91f8/10864086/68237ec08aa5/1349-7235-63-0299-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91f8/10864086/dd8570b8ec5d/1349-7235-63-0299-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91f8/10864086/0b6de5f13049/1349-7235-63-0299-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91f8/10864086/68237ec08aa5/1349-7235-63-0299-g003.jpg

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