Neonatal Netw. 2023 Jun 1;42(3):156-164. doi: 10.1891/NN-2022-0024.
Congenital syphilis (CS) infection occurs by way of vertical transmission of the bacteria from mother to fetus. While nearly eliminated by the turn of the twenty-first century, CS has resurged in recent years and currently represents a worldwide public health calamity secondary to insufficient prenatal care and inadequate maternal treatment. Fetal and neonatal consequences include stillbirth, cutaneous and visceral symptoms, asymptomatic infection, and death. Given the rise in cases in both wealthy and resource-poor areas, neonatal clinicians are obligated to maintain acumen specific to risk factors, manifestations, and treatment regimens. However, limited data guide postnatal treatment regimens, particularly in preterm neonates. We present a case report of a preterm female with CS and integrated review of the literature. Our findings indicate that CS is preventable through efficient and judicious perinatal screening, early detection, and adequate treatment of maternal syphilis during pregnancy.
先天性梅毒（CS）感染是通过细菌从母亲垂直传播到胎儿的方式发生的。虽然在 21 世纪初几乎被消除，但近年来 CS 又卷土重来，目前由于产前护理不足和孕产妇治疗不当，已成为全球公共卫生灾难。胎儿和新生儿的后果包括死产、皮肤和内脏症状、无症状感染和死亡。鉴于富裕和资源匮乏地区的病例都有所增加，新生儿临床医生有责任关注与危险因素、表现和治疗方案相关的特定知识。然而，有限的数据指导了新生儿的产后治疗方案，尤其是早产儿。我们报告了一例 CS 早产儿病例，并对文献进行了综合回顾。我们的研究结果表明，通过对孕妇进行有效的、有针对性的围产期筛查，早期发现和充分治疗梅毒，可以预防 CS。
