De Witte P, Gewiss M
Physiol Behav. 1986;36(6):1005-8. doi: 10.1016/0031-9384(86)90471-3.
Male Wistar rats were trained to discriminate intraperitoneal injections of 2 g/kg of alcohol from 0.5 g/kg alcohol injections. Intracranial stimulation in the posterolateral area of the hypothalamus served as the reinforcer according to a FR 10 schedule of bar pressing. After discrimination between the two alcohol doses had been established, the response-reinforcement contingency was modified by progressively increasing the intensity of the intracranial stimulation. The results indicate that the generalization gradient varies with the number of reinforcements. The more the lever associated with a training dose was reinforced, the more the ED50 had the tendency to approach this dose. Our paradigm, by using electrical brain reinforcer, allowed to deliver in an equal manner the reinforcement schedule in order to obtain equal performances and equal number of reward received.
雄性Wistar大鼠接受训练，以区分腹腔注射2克/千克酒精与0.5克/千克酒精注射。根据每按压10次杠杆给予一次强化的固定比率10程序，下丘脑后外侧区域的颅内刺激作为强化物。在确定了两种酒精剂量之间的辨别能力后，通过逐步增加颅内刺激的强度来改变反应-强化的关联性。结果表明，泛化梯度随强化次数而变化。与训练剂量相关的杠杆得到的强化越多，半数有效剂量（ED50）就越倾向于接近该剂量。我们的实验范式通过使用脑电强化物，能够以同等方式给予强化程序，以便获得同等的表现和同等数量的奖励。
