Jung Yoon Suk, Tran Mai Thi Xuan, Park Boyoung, Moon Chang Mo
Division of Gastroenterology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Republic of Korea.
J Gastroenterol Hepatol. 2023 Oct;38(10):1787-1793. doi: 10.1111/jgh.16251. Epub 2023 May 31.
We evaluated the associations between gastric cancer (GC) family history (FH) and colorectal cancer (CRC) risk and between CRC FH and GC/gastric adenoma risk.
We used data of participants who underwent national cancer screening between 2013 and 2014. Participants with GC or CRC FH in first-degree relatives (n = 1 172 750) and those without cancer FH (n = 3 518 250) were matched 1:3 by age and gender.
Of the 1 172 750 participants with a FH, 871 104, 264 040, and 37 606 had FHs of only GC, only CRC, and both GC and CRC, respectively. The median follow-up time was 4.8 years. GC and CRC FHs were associated with increased GC and CRC risks, respectively. GC FH was associated with CRC risk (adjusted hazard ratio 1.05; 95% confidence interval [CI] 1.01-1.10), whereas CRC FH was not associated with the risk of GC or gastric adenoma. However, gastric adenoma risk increased 1.62-fold (95% CI 1.40-1.87) in participants with FHs of both GC and CRC, demonstrating a significant difference with the 1.39-fold (95% CI 1.34-1.44) increase in participants with only GC FH. Furthermore, GC risk increased by 5.32 times (95% CI 1.74-16.24) in participants with FHs of both GC and CRC in both parents and siblings.
GC FH was significantly associated with a 5% increase in CRC risk. Although CRC FH did not increase GC risk, FH of both GC and CRC further increased the risk of gastric adenoma. FHs of GC and CRC may affect each other's neoplastic lesion risk.
我们评估了胃癌（GC）家族史（FH）与结直肠癌（CRC）风险之间以及CRC家族史与GC/胃腺瘤风险之间的关联。
我们使用了2013年至2014年期间接受全国癌症筛查的参与者的数据。有一级亲属患GC或CRC家族史的参与者（n = 1172750）和无癌症家族史的参与者（n = 3518250）按年龄和性别以1:3的比例进行匹配。
在1172750名有家族史的参与者中，分别有871104、264040和37606名参与者仅有GC家族史、仅有CRC家族史以及同时有GC和CRC家族史。中位随访时间为4.8年。GC家族史和CRC家族史分别与GC和CRC风险增加相关。GC家族史与CRC风险相关（调整后的风险比为1.05；95%置信区间[CI]为1.01 - 1.10），而CRC家族史与GC或胃腺瘤风险无关。然而，同时有GC和CRC家族史的参与者胃腺瘤风险增加了1.62倍（95% CI为1.40 - 1.87），与仅有GC家族史的参与者增加1.39倍（95% CI为1.34 - 1.44）相比有显著差异。此外，父母和兄弟姐妹均有GC和CRC家族史的参与者GC风险增加了5.32倍（95% CI为1.74 - 16.24）。
GC家族史与CRC风险显著增加5%相关。虽然CRC家族史未增加GC风险，但GC和CRC家族史会进一步增加胃腺瘤风险。GC和CRC家族史可能会相互影响彼此的肿瘤性病变风险。
