Wang Nan, Qiao Qing, Bao Guoqiang, Wu Tao, Li Yizhou, Li Jingjie, Lu Jianguo, He Xianli
Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi, 710038, China.
Inner Mongolia Medical University, Hohhot, Inner Mongolia, 010050, China.
Oncotarget. 2017 Apr 25;8(17):28805-28811. doi: 10.18632/oncotarget.15745.
Here, we genotyped eleven single-nucleotide polymorphisms (SNPs) and evaluated their association with the risk of developing gastric cancer (GC) or colorectal cancer (CRC) in 1,790 Han Chinese participants (588 GC patients, 499 CRC patients, and 703 healthy controls). Statistically analysis showed that the "C" allele of rs2689154 in MIPEPP2 was associated with a decreased risk of GC (odds ratio [OR] = 0.81, 95 % confidence interval [CI]: 0.66-0.99, P = 0.041), whereas the "T" allele of rs12615966 in LOC284998 was associated with a 1.29-fold increase in the risk of GC (OR = 1.29, 95% CI: 1.03-1.63, P = 0.029). Additionally, genetic model analyses showed that rs2689154 was associated with a reduced risk of GC under the recessive model (adjusted OR = 0.46, 95% CI: 0.22-0.98, P = 0.037), and rs12615966 in FOXF1 was associated with an increased risk of GC in both the dominant and log-additive models after adjusted for age and gender (adjusted OR = 1.36, 95% CI: 1.02-1.81, P = 0.033; adjusted OR = 1.36, 95% CI: 1.05-1.75, P = 0.018, respectively). We also observed that rs2178146 in FOXF1 was associated with an increased risk of CRC in the recessive model (adjusted OR = 1.90, 95% CI: 1.05-3.45, P = 0.034). Our results confirmed that rs2689154 in MIPEPP2 was significantly decreased GC risk, but rs12615966 in LOC284998 was significantly increased GC risk, and rs2178146 in FOXF1 was associated with increased CRC risk in the Han Chinese population.
在此，我们对11个单核苷酸多态性（SNP）进行了基因分型，并评估了它们与1790名汉族参与者（588例胃癌患者、499例结直肠癌患者和703名健康对照）发生胃癌（GC）或结直肠癌（CRC）风险的相关性。统计学分析表明，MIPEPP2基因中rs2689154的“C”等位基因与GC风险降低相关（优势比[OR]=0.81，95%置信区间[CI]：0.66 - 0.99，P = 0.041），而LOC284998基因中rs12615966的“T”等位基因与GC风险增加1.29倍相关（OR = 1.29，95% CI：1.03 - 1.63，P = 0.029）。此外，遗传模型分析显示，在隐性模型下rs2689154与GC风险降低相关（校正OR = 0.46，95% CI：0.22 - 0.98，P = 0.037），在调整年龄和性别后，FOXF1基因中的rs12615966在显性和对数加性模型中均与GC风险增加相关（校正OR = 1.36，95% CI：1.02 - 1.81，P = 0.033；校正OR = 1.36，95% CI：1.05 - 1.75，P = 0.018）。我们还观察到，在隐性模型下FOXF1基因中的rs2178146与CRC风险增加相关（校正OR = 1.90，95% CI：1.05 - 3.45，P = 0.034）。我们的结果证实，MIPEPP2基因中的rs2689154显著降低了GC风险，但LOC284998基因中的rs12615966显著增加了GC风险，并且FOXF1基因中的rs2178146与汉族人群中CRC风险增加相关。
