Interactions of alumina and polystyrene nanoparticles with the innate immune system of .

Nowadays, particularly metallic, and polymeric nanoparticles (NPs) are widely produced and used in many fields. Due to the increase in both their usage and diversity, their release and accumulation in the environment are also accelerating. Therefore, their interactions with cells, especially immune cells, and their health risks are not fully understood. The impacts of metallic alumina (Al) NPs and polystyrene (PS) NPs obtained after the polymerization of carcinogenic styrene on living organisms have not yet been elucidated. larvae can biodegrade plastics. While biodegradation and solving the waste problem have attracted much attention, the interactions of this distinctive property of larvae in the immune system and ecosystem are not yet completely understood. Al and PS NPs were applied to separately. Al NPs were purchased and PS NPs were prepared from PS by single-emulsion technique and characterized. Then LC values of these NPs on were determined. The interactions of these NPs with encapsulation, melanization, and phenoloxidase activity, which express innate immune responses in larvae, were revealed. NP exposure resulted in suppression of the immune response, probably because it affects the functions of hemocytes such as enzymatic activation, hemocyte division, and populations. In this context, our data suggest that Al and PS NPs induce toxic impacts and negatively alter the physiological status of . It is also shown that has the potential to be an impactful alternative model for biosafety and nanotoxicology studies.