Department of Biology, Kocaeli University, Kocaeli, Türkiye.
Department of Polymer Science and Technology, Kocaeli University, Kocaeli, Türkiye.
Drug Chem Toxicol. 2024 Sep;47(5):483-495. doi: 10.1080/01480545.2023.2217484. Epub 2023 Jun 1.
Nowadays, particularly metallic, and polymeric nanoparticles (NPs) are widely produced and used in many fields. Due to the increase in both their usage and diversity, their release and accumulation in the environment are also accelerating. Therefore, their interactions with cells, especially immune cells, and their health risks are not fully understood. The impacts of metallic alumina (Al) NPs and polystyrene (PS) NPs obtained after the polymerization of carcinogenic styrene on living organisms have not yet been elucidated. larvae can biodegrade plastics. While biodegradation and solving the waste problem have attracted much attention, the interactions of this distinctive property of larvae in the immune system and ecosystem are not yet completely understood. Al and PS NPs were applied to separately. Al NPs were purchased and PS NPs were prepared from PS by single-emulsion technique and characterized. Then LC values of these NPs on were determined. The interactions of these NPs with encapsulation, melanization, and phenoloxidase activity, which express innate immune responses in larvae, were revealed. NP exposure resulted in suppression of the immune response, probably because it affects the functions of hemocytes such as enzymatic activation, hemocyte division, and populations. In this context, our data suggest that Al and PS NPs induce toxic impacts and negatively alter the physiological status of . It is also shown that has the potential to be an impactful alternative model for biosafety and nanotoxicology studies.
如今，特别是金属和聚合物纳米粒子（NPs）被广泛生产和应用于许多领域。由于它们的使用和种类不断增加，它们在环境中的释放和积累也在加速。因此，它们与细胞的相互作用，特别是免疫细胞的相互作用，以及它们的健康风险还不完全清楚。聚合致癌苯乙烯后得到的金属氧化铝（Al）NPs 和聚苯乙烯（PS）NPs 对生物体的影响尚未阐明。幼虫可以生物降解塑料。虽然生物降解和解决废物问题引起了广泛关注，但幼虫这一独特特性在免疫系统和生态系统中的相互作用还不完全清楚。将 Al 和 PS NPs 分别应用于幼虫。Al NPs 是购买的，PS NPs 是通过单乳液技术从 PS 制备的，并进行了表征。然后测定了这些 NPs 在幼虫中的 LC 值。揭示了这些 NPs 与包封、黑化和酚氧化酶活性的相互作用，这些反应表达了幼虫的先天免疫反应。NP 暴露导致免疫反应受到抑制，这可能是因为它影响了血细胞的功能，如酶的激活、血细胞分裂和种群。在这种情况下，我们的数据表明 Al 和 PS NPs 会产生毒性影响，并对 的生理状态产生负面影响。研究还表明，幼虫具有成为生物安全性和纳米毒理学研究有影响力的替代模型的潜力。
