Thomas D E, Chung-A-On K O, Dickerson J W, Tidmarsh S F, Shaw D M
Psychol Med. 1986 May;16(2):297-305. doi: 10.1017/s0033291700009119.
The nutritional status of 23 severely demented patients was compared with that of 23 similarly aged controls in the community. A 3-day weighed intake on all subjects showed lower mean intakes of energy, protein, ascorbic acid and nicotinic acid in the mean intakes of energy, protein, ascorbic acid and nicotinic acid in the patient group. This group had lower levels of plasma ascorbic acid and red cell folate and of urinary N-methylnicotinamide excretion relative to creatinine. Over a third of both controls and patients had evidence of thiamin deficiency, as judged by a raised percentage erythrocyte transketolase activity. An earlier finding in patients with senile dementia of reduced fasting plasma concentrations of tryptophan was confirmed for total and protein bound fractions. With the possible exception of ascorbic acid, the data could not be explained satisfactorily in terms of intake. It is suggested that the association between the phenomena of aging, senile dementia and nutritional status merits further investigation.
将23名重度痴呆患者的营养状况与社区中23名年龄相仿的对照组进行了比较。对所有受试者进行的3天称重摄入量调查显示，患者组的能量、蛋白质、抗坏血酸和烟酸平均摄入量较低。该组血浆抗坏血酸、红细胞叶酸水平以及尿中N-甲基烟酰胺相对于肌酐的排泄量均较低。根据红细胞转酮醇酶活性百分比升高判断，超过三分之一的对照组和患者有硫胺素缺乏的证据。对于总色氨酸和蛋白质结合部分，老年痴呆患者空腹血浆浓度降低这一早期发现得到了证实。除抗坏血酸外，这些数据无法根据摄入量得到令人满意的解释。有人提出，衰老、老年痴呆和营养状况之间的关联值得进一步研究。
