Joffe R T, Uhde T W, Post R M, Minichiello M D
Biol Psychiatry. 1987 Aug;22(8):941-6. doi: 10.1016/0006-3223(87)90003-5.
Motor activity in 19 depressed patients treated with carbamazepine was assessed using self-contained monitors worn on the wrist. Those whose depression improved demonstrated significant increases in motor activity. Nonresponders as a group did not show decreased motor activity, suggesting that carbamazepine was not producing sedation or hypoactivity at clinically relevant doses. Activity counts were negatively correlated with ratings of global severity of depression on the Bunney-Hamburg Scale and with degree of motor retardation rated on the BPRS during treatment. The selective increases in motor activity in those who improved are consistent with psychomotor changes related to amelioration of depression.
使用佩戴在手腕上的独立监测器评估了19名接受卡马西平治疗的抑郁症患者的运动活动。抑郁症有所改善的患者运动活动显著增加。作为一个群体，无反应者并未表现出运动活动减少，这表明卡马西平在临床相关剂量下不会产生镇静作用或活动减退。治疗期间，活动计数与Bunney-Hamburg量表上的总体抑郁严重程度评分以及BPRS上评定的运动迟缓程度呈负相关。病情改善者运动活动的选择性增加与抑郁症改善相关的精神运动变化一致。
