Department of Psychiatry Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Department of Neurology Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Med Arch. 2023 Apr;77(2):123-126. doi: 10.5455/medarh.2023.77.123-126.
Schizophrenia is chronic and debilitating psychiatric disorder, characterized by a constellation of clinical signs and symptoms that are categorized into distinct positive, negative, disorganization and cognitive symptom domains. The outcome of the disease is better in female patients compared to male patients who have a higher risk of rehospitalization and twice as long duration of hospital treatment. In male patients with schizophrenia an earlier onset of the disease, negative symptoms and a more severe clinical picture are noted, with a less promising therapeutic response to neuroleptics. The onset of negative symptoms is more variable.
The aim of the study was to determine the correlation of positive and negative symptoms (PANSS scores) in patients with schizophrenia according to gender.
The sample included 40 subjects with schizophrenia (21 males; 19 females). The study was conducted at the Department of Psychiatry Clinical Center University of Sarajevo.
All male subjects have a PANSS negative symptoms score of 17 or higher, while all female subjects have a PANSS negative symptoms score of less than 17. While the difference in the variances is not statistically significant, the results show that the difference in the average values of the PANSS symptom score between male and female subjects is statistically significant for both positive and negative symptoms (p=0.026).
Diminished sociality, emotional responsiveness, and drive during childhood have been reported in a substantial minority of patients with schizophrenia. This aspect of the illness may account for the low level of emotional expression and neuromotor dysfunction in infants who subsequently have schizophrenia. In other patients, the negative symptoms first occur after the onset of psychosis.
精神分裂症是一种慢性且使人虚弱的精神疾病，其特征是一系列临床体征和症状，这些症状可分为明显的阳性、阴性、紊乱和认知症状领域。与男性患者相比，女性患者的疾病结局更好，男性患者有更高的再住院风险和两倍长的住院治疗时间。患有精神分裂症的男性患者，疾病发作较早，阴性症状更严重，对神经安定剂的治疗反应较差。阴性症状的发作更为多变。
本研究的目的是根据性别确定精神分裂症患者阳性和阴性症状（PANSS 评分）之间的相关性。
该样本包括 40 名精神分裂症患者（21 名男性；19 名女性）。该研究在萨拉热窝大学临床中心精神病学部进行。
所有男性患者的 PANSS 阴性症状评分均为 17 或更高，而所有女性患者的 PANSS 阴性症状评分均低于 17。虽然方差的差异没有统计学意义，但结果表明，男性和女性患者的 PANSS 症状评分平均值之间的差异在阳性和阴性症状方面均具有统计学意义（p=0.026）。
在相当一部分精神分裂症患者中，已经报道了童年时期社交能力下降、情感反应能力下降和驱动力下降。这种疾病的这一方面可能解释了随后患有精神分裂症的婴儿中情绪表达和神经运动功能障碍水平较低的原因。在其他患者中，阴性症状首先在精神病发作后出现。
