Cadnapaphornchai Melissa A, Ong Albert C M
Rocky Mountain Pediatric Kidney Center, Rocky Mountain Hospital for Children at Presbyterian St. Luke's Medical Center, Denver, CO, USA.
Academic Nephrology Unit, Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, UK.
Clin Kidney J. 2023 Mar 16;16(6):901-904. doi: 10.1093/ckj/sfad049. eCollection 2023 Jun.
ADPKD is the most common hereditary kidney disease and a major cause of kidney failure world-wide. Significant kidney enlargement occurs decades preceding loss of kidney function. However, the earliest clinical manifestations of disease have been less well characterized in young adults, a typically healthy population who do not often seek routine medical care. In this study, Martinez and colleagues report a high prevalence of hypertension among young adults (18-30 years) enrolled in the Spanish ADPKD registry REPQRAD. Their findings confirm previous studies in children and young adults with ADPKD and make a strong case for earlier screening and intervention within this age group.
常染色体显性多囊肾病（ADPKD）是最常见的遗传性肾病，也是全球肾衰竭的主要病因。在肾功能丧失前数十年，肾脏会显著增大。然而，在年轻成年人（这是一个通常健康且不常寻求常规医疗护理的人群）中，该疾病最早的临床表现尚未得到充分描述。在这项研究中，马丁内斯及其同事报告称，纳入西班牙ADPKD注册登记处REPQRAD的年轻成年人（18至30岁）中高血压患病率很高。他们的研究结果证实了先前针对患有ADPKD的儿童和年轻成年人的研究，并有力地支持了在该年龄组中进行早期筛查和干预。
