Ghyka G, Boeras F, Călugăru A, Savi I, Moraru I
Med Interne. 1986 Apr-Jun;24(2):143-6.
Ginterferon is a human leukocyte interferon (IFN) produced in the "V. Babes" Institute by in vitro culture of leukocytes separated from neonatal cord blood. Ginterferon (50,000 IU/ml) was administered to 40 patients who suffered for at least two weeks of a hepatic keratoconjunctivitis resistant to treatment with conventional regimens of human immunoglobulins, Iduviran or topical antiinflammatory drugs. In 35 cases (87%) complete recovery (total epithelialization and disappearance of all symptoms) occurred in a significantly shorter time (10-14 days) as compared to similar cases which recovered after 30-40 days by conventional treatment. Local or general untoward effects were not observed in any of the patients. Recovery in the remaining 5 cases was slower, 28-30 days. This slow response may have been due to unusual weakness of the general immunobiological condition in these patients (myocardial infarction or repeated stress) which might have favoured repeated waves of virus spreads from foci of viral latency which are not attained by the topically administered IFN.
金干扰素是一种人白细胞干扰素（IFN），由“V. 巴贝斯”研究所通过体外培养从新生儿脐带血中分离出的白细胞而产生。对40例患有至少两周对人免疫球蛋白、碘苷或局部抗炎药物常规治疗方案耐药的肝性角膜结膜炎的患者给予金干扰素（50,000国际单位/毫升）。与通过常规治疗30 - 40天恢复的类似病例相比，35例（87%）患者在显著更短的时间（10 - 14天）内实现了完全康复（上皮完全化且所有症状消失）。所有患者均未观察到局部或全身不良反应。其余5例患者恢复较慢，为28 - 30天。这种缓慢反应可能是由于这些患者总体免疫生物学状况异常虚弱（心肌梗死或反复应激），这可能有利于病毒从局部应用的干扰素无法到达的病毒潜伏灶反复传播。
