Department of Industry Engineering, School of Mechanical Engineering, Northwestern Polytechnical University, 127 West Youyi Road, Xi'an, Shaanxi 710072, P. R. China.
Department of Hematology, Xi'an Gaoxin Hospital, No. 16 South Road, Xi'an, Shaanxi 710077, P. R. China.
ACS Biomater Sci Eng. 2023 Jun 12;9(6):3032-3057. doi: 10.1021/acsbiomaterials.3c00051. Epub 2023 Jun 1.
In recent years, bioactive ceramic bone scaffolds have drawn remarkable attention as an alternative method for treating and repairing bone defects. Vat photopolymerization (VP) is a promising additive manufacturing (AM) technique that enables the efficient and accurate fabrication of bioactive ceramic bone scaffolds. This review systematically reviews the research progress of VP-printed bioactive ceramic bone scaffolds. First, a summary and comparison of commonly used bioactive ceramics and different VP techniques are provided. This is followed by a detailed introduction to the preparation of ceramic suspensions and optimization of printing and heat treatment processes. The mechanical strength and biological performance of the VP-printed bioactive ceramic scaffolds are then discussed. Finally, current challenges and future research directions in this field are highlighted.
近年来,生物活性陶瓷骨支架作为治疗和修复骨缺损的一种替代方法引起了人们的极大关注。光固化立体造型(VP)是一种很有前途的增材制造(AM)技术,能够高效、准确地制造生物活性陶瓷骨支架。本文系统地综述了 VP 打印的生物活性陶瓷骨支架的研究进展。首先,对常用的生物活性陶瓷和不同的 VP 技术进行了总结和比较。接着详细介绍了陶瓷悬浮液的制备和打印及热处理工艺的优化。然后讨论了 VP 打印的生物活性陶瓷支架的机械强度和生物性能。最后,强调了该领域目前的挑战和未来的研究方向。