星形胶质细胞终足中的高钾电导。
High potassium conductance in astrocyte endfeet.
作者信息
Newman E A
出版信息
Science. 1986 Jul 25;233(4762):453-4. doi: 10.1126/science.3726539.
Abstract
The distribution of potassium conductance over the surface of freshly dissociated salamander astrocytes was determined by monitoring cell depolarizations evoked by focal increases in the extracellular potassium concentration. The specific potassium conductance of the endfoot processes of these cells was approximately tenfold higher than the conductance of other cell regions. This dramatically nonuniform conductance distribution may play an important role in the regulation of extracellular potassium levels by glia in the brain.
摘要
通过监测细胞外钾离子浓度局部升高所诱发的细胞去极化，确定了新鲜解离的蝾螈星形胶质细胞表面钾离子电导的分布。这些细胞终足突起的比钾离子电导比其他细胞区域的电导高约十倍。这种显著的非均匀电导分布可能在大脑中胶质细胞对细胞外钾离子水平的调节中起重要作用。
相似文献
1
High potassium conductance in astrocyte endfeet.星形胶质细胞终足中的高钾电导。
Science. 1986 Jul 25;233(4762):453-4. doi: 10.1126/science.3726539.
2
Distribution of potassium conductance in mammalian Müller (glial) cells: a comparative study.哺乳动物米勒（神经胶质）细胞中钾离子电导的分布：一项比较研究。
J Neurosci. 1987 Aug;7(8):2423-32.
3
Potassium conductance in Müller cells of fish.鱼类米勒细胞中的钾离子电导
Glia. 1988;1(4):275-81. doi: 10.1002/glia.440010406.
4
Regional specialization of the membrane of retinal glial cells and its importance to K+ spatial buffering.视网膜神经胶质细胞膜的区域特化及其对钾离子空间缓冲的重要性。
Ann N Y Acad Sci. 1986;481:273-86. doi: 10.1111/j.1749-6632.1986.tb27158.x.
5
Does the release of potassium from astrocyte endfeet regulate cerebral blood flow?星形胶质细胞终足释放钾离子是否调节脑血流量？
Science. 1987 Aug 21;237(4817):896-8. doi: 10.1126/science.3616619.
6
Membrane physiology of retinal glial (Müller) cells.视网膜神经胶质（穆勒）细胞的膜生理学
J Neurosci. 1985 Aug;5(8):2225-39. doi: 10.1523/JNEUROSCI.05-08-02225.1985.
7
Freshly dissociated mature hippocampal astrocytes exhibit passive membrane conductance and low membrane resistance similarly to syncytial coupled astrocytes.刚解离的成熟海马星形胶质细胞表现出与合胞体耦合星形胶质细胞相似的被动膜电导和低膜电阻。
J Neurophysiol. 2015 Jun 1;113(10):3744-50. doi: 10.1152/jn.00206.2015. Epub 2015 Mar 25.
8
On the electrical passivity of astrocyte potassium conductance.星形胶质细胞钾电导的电被动性。
J Neurophysiol. 2021 Oct 1;126(4):1403-1419. doi: 10.1152/jn.00330.2021. Epub 2021 Sep 15.
9
Intermediate-conductance calcium-activated potassium channels participate in neurovascular coupling.中电导钙激活钾通道参与神经血管耦合。
Br J Pharmacol. 2011 Oct;164(3):922-33. doi: 10.1111/j.1476-5381.2011.01447.x.
10
The resting membrane parameters of human intercostal muscle at low, normal, and high extracellular potassium.低、正常和高细胞外钾浓度下人肋间肌的静息膜参数。
Muscle Nerve. 1984 Jan;7(1):60-5. doi: 10.1002/mus.880070110.
引用本文的文献
1
Insulin and leptin acutely modulate the energy metabolism of primary hypothalamic and cortical astrocytes.胰岛素和瘦素可急性调节原代下丘脑和皮质星形胶质细胞的能量代谢。
J Neurochem. 2025 Jan;169(1):e16211. doi: 10.1111/jnc.16211. Epub 2024 Aug 22.
2
From Physiology to Pathology of Astrocytes: Highlighting Their Potential as Therapeutic Targets for CNS Injury.从星形胶质细胞的生理学到病理学：凸显其作为中枢神经系统损伤治疗靶点的潜力
Neurosci Bull. 2025 Jan;41(1):131-154. doi: 10.1007/s12264-024-01258-3. Epub 2024 Jul 30.
3
Dysregulation of extracellular potassium distinguishes healthy ageing from neurodegeneration.细胞外钾离子的失调将健康衰老与神经退行性变区分开来。
Brain. 2024 May 3;147(5):1726-1739. doi: 10.1093/brain/awae075.
4
Effect of epiretinal electrical stimulation on the glial cells in a rabbit retinal eyecup model.视网膜前电刺激对兔视网膜眼杯模型中神经胶质细胞的影响。
Front Neurosci. 2024 Jan 22;18:1290829. doi: 10.3389/fnins.2024.1290829. eCollection 2024.
5
Altered calcium signaling in Bergmann glia contributes to spinocerebellar ataxia type-1 in a mouse model of SCA1.在脊髓小脑共济失调1型（SCA1）小鼠模型中，伯格曼胶质细胞中钙信号的改变导致了1型脊髓小脑共济失调。
Neurobiol Dis. 2023 Oct 15;187:106318. doi: 10.1016/j.nbd.2023.106318. Epub 2023 Oct 5.
6
Aß Pathology and Neuron-Glia Interactions: A Synaptocentric View.淀粉样变病理学与神经元-胶质相互作用：以突触为中心的观点。
Neurochem Res. 2023 Apr;48(4):1026-1046. doi: 10.1007/s11064-022-03699-6. Epub 2022 Aug 17.
7
CADASIL mutations sensitize the brain to ischemia via spreading depolarizations and abnormal extracellular potassium homeostasis.CADASIL 突变通过扩散性去极化和异常细胞外钾离子动态平衡使大脑对缺血敏感。
J Clin Invest. 2022 Apr 15;132(8). doi: 10.1172/JCI149759.
8
Amyloid-β plaques affect astrocyte Kir4.1 protein expression but not function in the dentate gyrus of APP/PS1 mice.淀粉样β斑块影响 APP/PS1 小鼠齿状回星形胶质细胞 Kir4.1 蛋白的表达，但不影响其功能。
Glia. 2022 Apr;70(4):748-767. doi: 10.1002/glia.24137. Epub 2022 Jan 4.
9
OnabotulinumtoxinA affects cortical recovery period but not occurrence or propagation of cortical spreading depression in rats with compromised blood-brain barrier.在血脑屏障受损的大鼠中，A型肉毒杆菌毒素影响皮层恢复期，但不影响皮层扩散性抑制的发生或传播。
Pain. 2021 Sep 1;162(9):2418-2427. doi: 10.1097/j.pain.0000000000002230.
10
The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes.脑毛细血管周细胞的离子通道和G蛋白偶联受体工具包
Front Cell Neurosci. 2020 Dec 18;14:601324. doi: 10.3389/fncel.2020.601324. eCollection 2020.
本文引用的文献
1
The fine anatomy of the optic nerve of anurans--an electron microscope study.无尾两栖类视神经的精细解剖——一项电子显微镜研究
J Biophys Biochem Cytol. 1960 Feb;7(1):107-20. doi: 10.1083/jcb.7.1.107.
2
Analysis of potassium dynamics in mammalian brain tissue.哺乳动物脑组织中钾动力学分析。
J Physiol. 1983 Feb;335:393-426. doi: 10.1113/jphysiol.1983.sp014541.
3
Regional specialization of retinal glial cell membrane.视网膜神经胶质细胞膜的区域特化
Nature. 1984;309(5964):155-7. doi: 10.1038/309155a0.
4
Astrocytes in primary cultures: membrane potential characteristics reveal exclusive potassium conductance and potassium accumulator properties.原代培养中的星形胶质细胞：膜电位特征揭示独特的钾离子电导和钾离子蓄积特性。
Brain Res. 1984 Feb 6;292(2):367-74. doi: 10.1016/0006-8993(84)90772-8.
5
Control of extracellular potassium levels by retinal glial cell K+ siphoning.视网膜神经胶质细胞通过钾离子虹吸作用对细胞外钾离子水平进行调控。
Science. 1984 Sep 14;225(4667):1174-5. doi: 10.1126/science.6474173.
6
Glial fibrillary acidic (GFA) protein in Müller glia. Immunofluorescence study of the goldfish retina.
Brain Res. 1984 May 21;300(1):175-8. doi: 10.1016/0006-8993(84)91355-6.
7
Transient changes in the size of the extracellular space in the sensorimotor cortex of cats in relation to stimulus-induced changes in potassium concentration.猫感觉运动皮层细胞外间隙大小的瞬时变化与刺激诱导的钾浓度变化的关系。
Exp Brain Res. 1980;40(4):432-9. doi: 10.1007/BF00236151.
8
Current source-density analysis of the b-wave of frog retina.蛙视网膜b波的电流源密度分析
J Neurophysiol. 1980 May;43(5):1355-66. doi: 10.1152/jn.1980.43.5.1355.
9
Effect of nerve impulses on the membrane potential of glial cells in the central nervous system of amphibia.神经冲动对两栖动物中枢神经系统中神经胶质细胞膜电位的影响。
J Neurophysiol. 1966 Jul;29(4):788-806. doi: 10.1152/jn.1966.29.4.788.
10
Astrocyte-specific protein and neuroglial differentiation. An immunofluorescence study with antibodies to the glial fibrillary acidic protein.星形胶质细胞特异性蛋白与神经胶质分化。使用抗胶质纤维酸性蛋白抗体的免疫荧光研究。
J Comp Neurol. 1974 Jan 1;153(1):27-38. doi: 10.1002/cne.901530104.
Zotero 插件