Yang Yifei, Wang Yi, Zhao Long, Wang Fang, Li Mingxing, Wang Qin, Luo Haoming, Zhao Qianyun, Zeng Jiuping, Zhao Yueshui, Du Fukuan, Chen Yu, Shen Jing, Wei Shulin, Xiao Zhangang, Wu Xu
Laboratory of Molecular Pharmacology, Department of Pharmacology, School of Pharmacy, Southwest Medical University, Luzhou 646000, China.
Luzhou Key Laboratory of Cell Therapy & Cell Drugs, Luzhou 646000, China.
Chin Herb Med. 2023 Mar 28;15(2):181-200. doi: 10.1016/j.chmed.2023.03.003. eCollection 2023 Apr.
Ulcerative colitis (UC) is one of types of inflammatory bowel disease with high recurrence. Recent studies have highlighted that microbial dysbiosis as well as abnormal gut immunity are crucial factors that initiate a series of inflammatory responses in the UC. Modulating the gut microbiota-intestinal immunity loop has been suggested as one of key strategies for relieving UC. Many Chinese herbal medicines including some of single herb, herbal formulas and the derived constituents have been reported with protective effect against UC through modulating gut microbiome and intestinal immunity. Some clinical trials have shown promising results. This review thus focused on the current knowledge on using Chinese herbal medicines for treating UC from the mechanism aspects of regulating intestinal homeostasis involving microbiota and gut immunity. The existing clinical trials are also summarized.
溃疡性结肠炎（UC）是炎症性肠病的一种，复发率很高。最近的研究强调，微生物群落失调以及肠道免疫异常是引发UC一系列炎症反应的关键因素。调节肠道微生物群-肠道免疫环路已被认为是缓解UC的关键策略之一。许多中药，包括一些单味草药、中药复方及其衍生成分，已被报道可通过调节肠道微生物群和肠道免疫对UC具有保护作用。一些临床试验已显示出有前景的结果。因此，本综述从调节涉及微生物群和肠道免疫的肠道稳态机制方面，聚焦于目前使用中药治疗UC的相关知识。同时也总结了现有的临床试验。
