加拿大艾伯塔省养殖麋鹿中的腺病毒出血病。
Adenoviral hemorrhagic disease in a farmed elk in Alberta, Canada.
机构信息
Diagnostic Services Unit and Department of Veterinary Clinical and Diagnostic Sciences, University of Calgary Faculty of Veterinary Medicine, 11877 85th Street NW, Calgary, Alberta T3R 1J3 (Domshy, Davies); Canadian Food Inspection Agency, National Centre for Foreign Animal Disease, 1015 Arlington Street, Winnipeg, Manitoba R3E 3M4 (Lung, Nebroski, Kruczkiewicz, Ayilara); Department of Biological Sciences, University of Manitoba, 50 Sifton Road, Winnipeg, Manitoba R3T 2M5 (Lung); California Animal Health and Food Safety Laboratory, School of Veterinary Medicine, University of California Davis, 620 West Health Science Drive, Davis, California 95616, USA (Woods); Emerson Trail Veterinary Services, Box 509, Beaverlodge, Alberta T0H 0C0 (Lowe).
出版信息
Can Vet J. 2023 Jun;64(6):524-528.
Adenoviral hemorrhagic disease (AHD), caused by (OdAdV-1), affects captive and free-ranging cervids across North America. Here we present a case of AHD in a 6-month-old female elk calf from a farm in Alberta. Histopathology revealed multisystemic vasculitis with endothelial intranuclear inclusion bodies, pulmonary hemorrhage, and small intestinal hemorrhage characteristic of the acute systemic form of AHD. Immunohistochemistry was positive for OdAdV-1, confirming the diagnosis. Whole-genome sequencing of the virus was conducted for phylogenetic comparison. This is the 1st reported case of AHD in a farmed elk in Canada and the 1st reported case in an elk in Alberta. Key clinical message: Adenoviral hemorrhagic disease (AHD) is an emerging disease that should be investigated as a top differential when diagnosticians and veterinarians encounter young cervids found dead with pulmonary edema or hemorrhage and/or hemorrhagic enteropathy.
腺病毒出血病（AHD）由（OdAdV-1）引起，影响北美的圈养和自由放养的鹿科动物。在这里，我们报告了艾伯塔省一个农场的 6 个月大雌性麋鹿幼崽的 AHD 病例。组织病理学显示多系统血管炎伴内皮核内包涵体、肺出血和小肠出血，这是 AHD 急性全身性形式的特征。免疫组织化学对 OdAdV-1 呈阳性，确诊了该病例。对病毒进行了全基因组测序，以进行系统发育比较。这是加拿大首例农场养殖麋鹿的 AHD 报告病例，也是艾伯塔省首例麋鹿 AHD 报告病例。关键临床信息：腺病毒出血病（AHD）是一种新兴疾病，当诊断医生和兽医遇到肺部水肿或出血和/或出血性肠炎的死亡幼鹿时，应将其作为首要鉴别诊断进行调查。
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