德黑兰三级转诊中心住院的新冠肺炎患者的电解质异常：高镁血症作为死亡标志物：一项回顾性横断面研究

Electrolyte abnormalities in hospitalized COVID-19 patients at tertiary referral centers in Tehran: Hypermagnesemia as a marker of fatality: A retrospective cross-sectional study.

作者信息

Mardani Sayna, Hakamifard Atousa, Aghazadeh Sarhangipour Kouros, Mardani Masoud

机构信息

Department of Infectious Diseases and Tropical Medicine, School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran.

Department of Infectious Diseases and Tropical Medicine, School of Medicine Isfahan University of Medical Sciences Isfahan Iran.

出版信息

Health Sci Rep. 2023 May 31;6(6):e1311. doi: 10.1002/hsr2.1311. eCollection 2023 Jun.

DOI:10.1002/hsr2.1311

PMID:37266063

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10230426/

Abstract

BACKGROUND AND AIMS

To evaluate biochemical abnormalities and their association with the outcome of hospitalized coronavirus disease 2019 (COVID-19) patients at a tertiary referral center in Iran.

METHODS

This retrospective study was conducted on COVID-19 patients who were admitted at tertiary referral centers in Tehran, Iran, from March 2021 to 2022. Demographic and biochemical laboratory data of the patients including blood sodium, potassium, calcium, and magnesium were collected from patient treatment sheets of severe COVID-19 patients admitted to a different ward of the hospital. A logistic regression model was fitted to identify the associated parameters with mortality.

RESULTS

Four hundred and ninety-nine patients with COVID-19, including 287 males (57.5%), who had a mean age of 58.95 ± 16.60 years, were enrolled. Thirty-eight patients (7.62%) died during hospitalization. The factors we found to be independently associated with an increased risk of in-hospital death were having comorbidity (mortality of 94.7%, vs. 61% among those without comorbidity; odds ratio, 17.71; 95% confidence interval [CI], 3.81-82.37), hypermagnesemia (34.2%, vs. 26.2% among those with normal magnesium; odds ratio, 9.71; 95% CI, 2.958-31.91), and having a male gender (34.2%, vs. 26.2% among those were female; odds ratio, 9.71; 95% CI, 2.958-31.91).

CONCLUSIONS

Hypermagnesemia, having a male gender, and the existence of comorbidity in patients with COVID-19 is associated with an increase in mortality. Further studies on the pathogenic mechanisms and therapeutic implications need to be done.

摘要

背景与目的

评估伊朗一家三级转诊中心收治的2019冠状病毒病（COVID-19）患者的生化异常情况及其与预后的关联。

方法

本回顾性研究针对2021年3月至2022年在伊朗德黑兰三级转诊中心收治的COVID-19患者开展。从收治于医院不同病房的重症COVID-19患者的治疗记录单中收集患者的人口统计学和生化实验室数据，包括血钠、血钾、血钙和血镁。采用逻辑回归模型确定与死亡率相关的参数。

结果

共纳入499例COVID-19患者，其中男性287例（57.5%），平均年龄58.95±16.60岁。38例患者（7.62%）在住院期间死亡。我们发现与院内死亡风险增加独立相关的因素包括合并症（死亡率94.7%，无合并症者为61%；比值比，17.71；95%置信区间[CI]，3.81 - 82.37）、高镁血症（34.2%，血镁正常者为26.2%；比值比，9.71；95%CI，2.958 - 31.91）以及男性（34.2%，女性为26.2%；比值比，9.71；95%CI，2.958 - 31.91）。