National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, China.
Invest Ophthalmol Vis Sci. 2023 Jun 1;64(7):7. doi: 10.1167/iovs.64.7.7.
The purpose of this study was to evaluate and explore the determinants of choroidal vascularity and choriocapillaris perfusion in a Chinese population aged 8 to 30 years old.
Three hundred eighty eyes from 380 subjects aged 8 to 30 years were included in this cross-sectional study. Submacular choroidal thickness (ChT), total choroidal area (TCA), luminal area (LA), stromal area (SA), choroidal vascularity index (CVI), and choriocapillaris flow deficit (CcFD) were estimated using images obtained from optical coherence tomography (OCT).
In this population, the mean ChT was 260.4 ± 63.3 µm, TCA was 1.56 ± 0.38 mm2, LA was 0.94 ± 0.25 mm2, and SA was 0.62 ± 0.15 mm2. The mean CVI was 60.25 ± 3.21% and CcFD was 11.95 ± 1.98%. Multivariable analyses showed that higher CVI and LA was associated with older age, thicker ChT, and shorter AL; and lower CcFD was associated with shorter AL. However, the associations were not uniformly rectilinear between CcFD and age. Specifically, CcFD was positively associated with age in subjects ≤19 years old and negatively associated with age in subjects >19 years old.
Development of the choroidal medium- and large-sized vascular layers and choriocapillaris was different across patients aged 8 to 30 years old. Greater axial length was associated with attenuated choroidal circulation. Choroidal thickness correlated well with choroidal vascularity, but not with choriocapillaris perfusion. Further comprehensive and longitudinal assessment of choroidal vasculature and choriocapillaris perfusion will help greatly to understand the physiological and pathological mechanisms responsible for myopia.
本研究旨在评估和探讨 8 至 30 岁中国人群脉络膜血管密度和脉络膜毛细血管灌注的决定因素。
本横断面研究纳入了 380 名 8 至 30 岁受试者的 380 只眼。采用光学相干断层扫描（OCT）图像测量黄斑下脉络膜厚度（ChT）、脉络膜总面积（TCA）、管腔面积（LA）、基质面积（SA）、脉络膜血管指数（CVI）和脉络膜毛细血管血流缺失（CcFD）。
在该人群中，平均 ChT 为 260.4±63.3μm，TCA 为 1.56±0.38mm2，LA 为 0.94±0.25mm2，SA 为 0.62±0.15mm2。平均 CVI 为 60.25±3.21%，CcFD 为 11.95±1.98%。多变量分析显示，较高的 CVI 和 LA 与年龄较大、ChT 较厚和眼轴较短有关；较低的 CcFD 与眼轴较短有关。然而，CcFD 与年龄之间的关系并非呈线性关系。具体来说，在≤19 岁的受试者中，CcFD 与年龄呈正相关，而在>19 岁的受试者中，CcFD 与年龄呈负相关。
8 至 30 岁患者脉络膜中、大血管层和脉络膜毛细血管的发育不同。较长的眼轴与脉络膜循环减弱有关。脉络膜厚度与脉络膜血管密度密切相关，但与脉络膜毛细血管灌注无关。进一步全面和纵向评估脉络膜血管和脉络膜毛细血管灌注将极大地帮助我们理解导致近视的生理和病理机制。
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