Chengdu University of TCM, Chengdu, Sichuan, China; Eye college of Chengdu University of TCM, Chengdu, Sichuan, China; Key Laboratory of Sichuan Province Ophthalmopathy Prevention & Cure and Visual Function Protection with TCM Laboratory, Chengdu, Sichuan, China.
Chengdu University of TCM, Chengdu, Sichuan, China; Eye college of Chengdu University of TCM, Chengdu, Sichuan, China; Ineye Hospital of Chengdu University of TCM, Chengdu, Sichuan, China; Key Laboratory of Sichuan Province Ophthalmopathy Prevention & Cure and Visual Function Protection with TCM Laboratory, Chengdu, Sichuan, China; Retinal Image Technology and Chronic Vascular Disease Prevention & Control and Collaborative Innovation Center, Chengdu, Sichuan, China.
Photodiagnosis Photodyn Ther. 2024 Aug;48:104275. doi: 10.1016/j.pdpdt.2024.104275. Epub 2024 Jul 11.
To measure the choroidal circulatory parameters Han Chinese children aged 4-14 years from Southwest China, and to explore the relationships between these parameters and age, axial length (AL), and choroidal thickness (ChT).
284 eyes from 142 subjects were included in this cross-sectional study. All participants underwent cycloplegic refraction and IOLMaster500 examination. Swept-source optical coherence tomography (SS-OCT) was used to measure submacular choroidal thickness, choroidal vascular volume (CVV), choroidal stromal volume (CSV), choroidal vascularity index (CVI), and CVV/CSV ratio.
In this population, the mean CVV was 2.92 ± 0.55 mm, CSV was 4.69 ± 0.68 mm, CVI was 38.22 ± 2.46 %, and CVV/CSV ratio was 62.11 ± 6.44 %. Multivariable regression analyses showed that both CVV and CSV were negatively correlated with AL (both P < 0.001) and positively correlated with ChT (both P < 0.001), while age showed no significant correlation with them (both P > 0.05). However, the correlations between CVI and age were not uniform rectilinear. Among participants aged ≤8 years, CVI showed no correlation with age (P > 0.05), while among those aged >8 years, it was positively correlated with age (P < 0.01). CVV/CSV ratio was positively correlated with ChT and age (both P < 0.01).
After the age of 8, age was positively correlated with CVI. ChT was well correlated with CVI. Longer AL and thinner ChT were associated with reduced CVV and CSV, with CVV decreasing more rapidly than CSV.
测量来自中国西南地区 4-14 岁汉族儿童的脉络膜循环参数，并探讨这些参数与年龄、眼轴（AL）和脉络膜厚度（ChT）之间的关系。
本横断面研究纳入了 142 名受试者的 284 只眼。所有参与者均接受睫状肌麻痹验光和 IOLMaster500 检查。使用扫频源光学相干断层扫描（SS-OCT）测量黄斑下脉络膜厚度、脉络膜血管容积（CVV）、脉络膜基质容积（CSV）、脉络膜血管指数（CVI）和 CVV/CSV 比值。
在该人群中，平均 CVV 为 2.92 ± 0.55mm，CSV 为 4.69 ± 0.68mm，CVI 为 38.22 ± 2.46%，CVV/CSV 比值为 62.11 ± 6.44%。多变量回归分析显示，CVV 和 CSV 均与 AL 呈负相关（均 P<0.001），与 ChT 呈正相关（均 P<0.001），而年龄与它们均无显著相关性（均 P>0.05）。然而，CVI 与年龄之间的相关性并非直线关系。在≤8 岁的参与者中，CVI 与年龄无相关性（P>0.05），而在>8 岁的参与者中，CVI 与年龄呈正相关（P<0.01）。CVV/CSV 比值与 ChT 和年龄呈正相关（均 P<0.01）。
8 岁以后，年龄与 CVI 呈正相关。ChT 与 CVI 相关性良好。较长的 AL 和较薄的 ChT 与 CVV 和 CSV 减少相关，CVV 减少速度快于 CSV。
