Department of Marine Bio-Food Sciences, Chonnam National University, Yeosu, 59626, Republic of Korea; Research Center for Healthcare and Biomedical Engineering, Chonnam National University, Yeosu, 59626, Republic of Korea.
Department of Pharmaceutical Engineering and Medical Science, Soonchunhyang University, Asan, 31538, Republic of Korea.
Appl Radiat Isot. 2023 Sep;199:110881. doi: 10.1016/j.apradiso.2023.110881. Epub 2023 May 30.
Thymus quinquecostatus Celak (TQC) is an aromatic herb, that possesses a wide range of biological properties. In the present study, we investigated the radio-protective effect of TQC water extract (TQCW) in gamma ray-exposed splenocytes, a peripheral immune cell and mice. Our results showed that the treatment with TQCW dose-dependently increased the viability of splenocytes. TQCW significantly increased the proliferation of splenocytes by reducing the production of intracellular reactive oxygen species (ROS) in 2 Gy-exposed splenocytes. Moreover, TQCW enhanced the hemopoietic system as increasing the number of endogenous spleen colony-forming units, and the number and the proliferation of splenocytes in 7 Gy-exposed mice. These results suggest that TQCW protects mice by enhancing the splenocytes proliferation and hemopoietic systems following exposure to gamma rays.
五裂叶荆芥（TQC）是一种具有广泛生物活性的芳香草本植物。在本研究中，我们研究了 TQC 水提取物（TQCW）对γ射线照射的脾细胞（外周免疫细胞）和小鼠的放射保护作用。结果表明，TQCW 可剂量依赖性地增加脾细胞活力。TQCW 通过减少 2Gy 照射脾细胞内活性氧（ROS）的产生，显著增加脾细胞的增殖。此外，TQCW 通过增加内源性脾集落形成单位的数量以及 7Gy 照射小鼠的脾细胞数量和增殖，增强了造血系统。这些结果表明，TQCW 通过增强γ射线照射后脾细胞的增殖和造血系统来保护小鼠。
