Xu Jie, Zhang Zhenghao, Ren Xiaofeng, Zhang Yunan, Zhou Yang, Lan Xiaorong, Guo Ling
Department of Oral Prosthodontics, The Affiliated Stomatological Hospital of Southwest Medical University, Luzhou, China.
Institute of Stomatology, Southwest Medical University, Luzhou, China.
Front Bioeng Biotechnol. 2023 Sep 28;11:1252574. doi: 10.3389/fbioe.2023.1252574. eCollection 2023.
Oral mucosal wounds exhibit an increased susceptibility to inflammation as a consequence of their direct exposure to a diverse range of microorganisms. This causes pain, slow healing, and other complications that interfere with patients' daily activities like eating and speaking. Consequently, patients experience a significant decline in their overall quality of life. Therefore, the pursuit of novel treatment approaches is of great importance. In this study, ginsenoside Rg1, a natural active substance extracted from ginseng root, was chosen as a therapeutic agent. It was encapsulated in a screened photo-crosslinked hydrogel scaffold for the treatment of mucosal defects in the rat palate. The results demonstrated that Rg1-hydrogel possessed excellent physical and chemical properties, and that oral mucosa wounds treated with Rg1-hydrogel exhibited the greatest healing performance, as evidenced by more pronounced wound re-epithelialization, increased collagen deposition, and decreased inflammatory infiltration. Subsequent investigations in molecular biology confirmed that Rg1-hydrogel stimulated the secretion of repair-related factors and inhibited the secretion of inflammatory factors. This study demonstrated that the hydrogel containing ginsenoside Rg1 significantly promotes oral mucosal tissue healing . Based on the findings, it can be inferred that the Rg1-hydrogel has promising prospects for the therapeutic management of oral mucosal wounds.
口腔黏膜伤口由于直接暴露于多种微生物而对炎症的易感性增加。这会导致疼痛、愈合缓慢以及其他并发症，进而干扰患者如进食和说话等日常活动。因此，患者的整体生活质量会显著下降。所以，寻求新的治疗方法至关重要。在本研究中，从人参根中提取的天然活性物质人参皂苷Rg1被选作治疗剂。它被包裹在经过筛选的光交联水凝胶支架中，用于治疗大鼠腭部的黏膜缺损。结果表明，Rg1 - 水凝胶具有优异的物理和化学性质，用Rg1 - 水凝胶治疗的口腔黏膜伤口表现出最佳的愈合性能，表现为伤口再上皮化更明显、胶原沉积增加以及炎症浸润减少。随后的分子生物学研究证实，Rg1 - 水凝胶刺激修复相关因子的分泌并抑制炎症因子的分泌。本研究表明，含人参皂苷Rg1的水凝胶能显著促进口腔黏膜组织愈合。基于这些发现，可以推断Rg1 - 水凝胶在口腔黏膜伤口的治疗管理方面具有广阔的前景。
