Faculty of Medicine, Wroclaw Medical University, Wroclaw, Poland.
Department of Molecular and Cellular Biology, Faculty of Pharmacy, Wroclaw Medical University, Wroclaw, Poland.
J Cell Biochem. 2023 Jun;124(6):765-784. doi: 10.1002/jcb.30413. Epub 2023 Jun 3.
Regulated cell death is an essential and heterogeneous process occurring in the life cycle of organisms, from embryonic development and aging to the regulation of homeostasis and organ maintenance. Under this term, we can distinguish many distinct pathways, including apoptosis and pyroptosis. Recently, there has been an increasing comprehension of the mechanisms governing these phenomena and their characteristic features. The coexistence of different types of cell death and the differences and similarities between them has been the subject of many studies. This review aims to present the latest literature in the field of pyroptosis and apoptosis and compare their molecular pathway's elements and significance in the physiology and pathophysiology of the organism.
程序性细胞死亡是生物生命周期中一种必要的、异质的过程，包括胚胎发育、衰老、内稳态调节和器官维持。在这个术语下，我们可以区分出许多不同的途径，包括细胞凋亡和细胞焦亡。最近，人们对这些现象的调控机制及其特征有了越来越多的认识。不同类型细胞死亡的共存以及它们之间的差异和相似性一直是许多研究的主题。本综述旨在介绍细胞焦亡和细胞凋亡领域的最新文献，并比较它们在机体生理和病理生理学中的分子途径的元素和意义。
