婴儿从出生到 24 个月的身体成分参考图表：多中心婴儿身体成分参考研究。
Body composition reference charts for infants from birth to 24 months: Multicenter Infant Body Composition Reference Study.
机构信息
Division of Human Health, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Vienna, Austria.
School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom.
出版信息
Am J Clin Nutr. 2023 Jun;117(6):1262-1269. doi: 10.1016/j.ajcnut.2023.02.012. Epub 2023 May 11.
BACKGROUND
Body composition assessment in the first 2 y of life provides important insights into child nutrition and health. The application and interpretation of body composition data in infants and young children have been challenged by a lack of global reference data.
OBJECTIVES
We aimed to develop body composition reference charts of infants aged 0-6 mo based on air displacement plethysmography (ADP) and those aged 3-24 mo based on total body water (TBW) by deuterium dilution (DD).
METHODS
Body composition was assessed by ADP in infants aged 0-6 mo from Australia, India, and South Africa. TBW using DD was assessed for infants aged 3-24 mo from Brazil, Pakistan, South Africa, and Sri Lanka. Reference charts and centiles were constructed for body composition using the lambda-mu-sigma method.
RESULTS
Sex-specific reference charts were produced for FM index (FMI), FFM index (FFMI), and percent FM (%FM) for infants aged 0-6 mo (n = 470 infants; 1899 observations) and 3-24 mo (n = 1026 infants; 3690 observations). When compared with other available references, there were observable differences but similar patterns in the trajectories of FMI, FFMI, and %FM.
CONCLUSIONS
These reference charts will strengthen the interpretation and understanding of body composition in infants across the first 24 mo of life.
背景
生命最初 2 年的人体成分评估可深入了解儿童营养和健康状况。由于缺乏全球参考数据，婴儿和幼儿的人体成分数据的应用和解释一直受到挑战。
目的
我们旨在根据空气置换体积描记法（ADP）制定 0-6 月龄婴儿的人体成分参考图表，并根据氘稀释法（DD）测定的全身水量（TBW）制定 3-24 月龄婴儿的人体成分参考图表。
方法
采用 ADP 对来自澳大利亚、印度和南非的 0-6 月龄婴儿进行人体成分评估，采用 DD 对来自巴西、巴基斯坦、南非和斯里兰卡的 3-24 月龄婴儿进行 TBW 评估。采用 lambda-mu-sigma 方法构建人体成分的 FM 指数（FMI）、FFM 指数（FFMI）和 FM%（%FM）参考图表和百分位数。
结果
为 0-6 月龄（n = 470 名婴儿；1899 次观测）和 3-24 月龄（n = 1026 名婴儿；3690 次观测）婴儿分别生成了 FM 指数（FMI）、FFM 指数（FFMI）和 FM%（%FM）的性别特异性参考图表。与其他现有参考值相比，FMI、FFMI 和%FM 的轨迹存在可观察到的差异，但模式相似。
结论
这些参考图表将加强对婴儿生命最初 24 个月期间人体成分的解释和理解。
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