[酒精中毒对大鼠组织及人体血液中抗坏血酸和脱氢抗坏血酸水平的影响]

[Effect of alcohol intoxication on ascorbic and dehydroascorbic acid levels in rat tissue. and human blood].

作者信息

Shugaleĭ Iu S, Degtiar V V, Butvin I N, Grivenko G P

出版信息

Ukr Biokhim Zh (1978). 1986 May-Jun;58(3):81-3.

Abstract

It is found that acute ethanol intoxication is accompanied by a decrease in the ascorbic acid content in the brain, liver and kidneys. The content of dehydroascorbic acid in kidneys in this case increases and in the brain tends to decrease. The chronic alcohol intoxication of rats has an opposite (as compared to the acute intoxication) effect on changes in the content of ascorbic and dehydroascorbic acids in the studied organs. People with chronic alcohol intoxication have the lower content of ascorbic acid in blood plasma and the higher content in erythrocytes, the content of dehydroascorbic acid being increased.

摘要

研究发现，急性乙醇中毒会伴随大脑、肝脏和肾脏中抗坏血酸含量的降低。在这种情况下，肾脏中脱氢抗坏血酸的含量增加，而大脑中的含量则趋于下降。与急性中毒相比，大鼠的慢性酒精中毒对所研究器官中抗坏血酸和脱氢抗坏血酸含量的变化具有相反的影响。慢性酒精中毒患者血浆中抗坏血酸含量较低，红细胞中含量较高，脱氢抗坏血酸含量增加。