人体血液中的脱氢抗坏血酸与糖尿病
Blood dehydroascorbic acid and diabetes mellitus in human beings.
作者信息
Banerjee A
出版信息
Ann Clin Biochem. 1982 Mar;19(Pt 2):65-70. doi: 10.1177/000456328201900201.
Ascorbic acid and dehydroascorbic acid were estimated in the blood of normal healthy subjects and diabetic patients. In normal subjects, blood contained only ascorbic acid while dehydroascorbic acid was practically absent. The ascorbic acid level was low in the blood of diabetic patients but the dehydroascorbic acid content was remarkably high, irrespective of age, sex, history of diabetes, or treatment. About 75% of blood dehydroascorbic acid was present in the erythrocytes: the rest was in plasma. High blood dehydroascorbic acid levels were also found in 90% of the non-diabetic offspring with both parents diabetic, in 24% of the non-diabetic offspring with one parent diabetic, and in 75% of the non-diabetic siblings of diabetic patients. It appears that, in persons having an hereditary predisposition to diabetes, high blood dehydroascorbic acid levels may be used as a marker for early detection of the disease.
对正常健康受试者和糖尿病患者的血液中的抗坏血酸和脱氢抗坏血酸进行了测定。在正常受试者中，血液中仅含有抗坏血酸，而几乎不存在脱氢抗坏血酸。糖尿病患者血液中的抗坏血酸水平较低，但脱氢抗坏血酸含量显著较高，与年龄、性别、糖尿病病史或治疗无关。血液中约75%的脱氢抗坏血酸存在于红细胞中，其余存在于血浆中。在父母双方均患有糖尿病的非糖尿病后代中，90%的人血液脱氢抗坏血酸水平较高；在父母一方患有糖尿病的非糖尿病后代中，24%的人血液脱氢抗坏血酸水平较高；在糖尿病患者的非糖尿病兄弟姐妹中，75%的人血液脱氢抗坏血酸水平较高。看来，在具有糖尿病遗传易感性的人群中，血液中脱氢抗坏血酸水平较高可作为该疾病早期检测的一个标志物。
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