“自发性糖尿病BB/W”Wistar大鼠红细胞中脱氢抗坏血酸的代谢与转运

Metabolism and transport of dehydroascorbic acid in erythrocytes of "spontaneous diabetic BB/W" Wistar rats.

作者信息

Rose R C

出版信息

Metabolism. 1986 Jul;35(7):619-21. doi: 10.1016/0026-0495(86)90167-8.

Abstract

Rates of uptake and reduction of dehydroascorbic acid in erythrocytes of "Spontaneous diabetic BB/W" and control Wistar rats were determined. Lysed cells reduced 14C-dehydroascorbic acid more rapidly than intact cells did, suggesting that membrane transport is a rate-limiting step. Diabetic rats had lower plasma levels of ascorbic acid but more rapid reduction of dehydroascorbic acid than control animals. The results indicate more rapid transport of dehydroascorbic acid into erythrocytes of prediabetic "BB/W" rats than Wistar rats.

摘要

测定了“自发性糖尿病BB/W”大鼠和对照Wistar大鼠红细胞中脱氢抗坏血酸的摄取率和还原率。裂解细胞比完整细胞更快地还原14C-脱氢抗坏血酸，这表明膜转运是一个限速步骤。糖尿病大鼠的血浆抗坏血酸水平较低，但脱氢抗坏血酸的还原速度比对照动物更快。结果表明，糖尿病前期“BB/W”大鼠红细胞中脱氢抗坏血酸的转运比Wistar大鼠更快。