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非编码 RNA 作为乳腺癌预后、诊断和临床应用的生物标志物的普遍性。

Non-coding RNA's prevalence as biomarkers for prognostic, diagnostic, and clinical utility in breast cancer.

机构信息

Department of Biosciences, Jamia Millia Islamia University, New Delhi, India.

Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, 62529, Saudi Arabia.

出版信息

Funct Integr Genomics. 2023 Jun 4;23(2):195. doi: 10.1007/s10142-023-01123-y.

Abstract

Noncoding RNAs (ncRNAs), which make up a significant portion of the mammalian transcriptome and plays crucial regulatory roles in expression of genes and other biological processes, have recently been found. The most extensively researched of the sncRNAs, microRNAs (miRNAs), have been characterized in terms of their synthesis, roles, and significance in the tumor development. Its crucial function in the stem cell regulation, another class of sncRNAs known as aspirRNAs, has attracted attention in cancer research. The investigations have shown that long non-coding RNAs have a crucial role in controlling developmental stages, such as mammary gland development. Additionally, it has been discovered that lncRNA dysregulation precedes the development of several malignancies, including breast cancer. The functions of sncRNAs (including miRNAs and piRNAs) and lncRNAs in the onset and development of the breast cancer are described in this study. Additionally, future perspectives of various ncRNA-based diagnostic, prognostic, and therapeutic approaches also discussed.

摘要

非编码 RNA(ncRNAs)构成了哺乳动物转录组的重要部分,在基因表达和其他生物过程中发挥着关键的调节作用,最近已经被发现。在 sncRNAs 中研究最多的是 microRNAs(miRNAs),它们的合成、作用及其在肿瘤发生中的意义已经得到了描述。另一类 sncRNAs 称为 aspirRNAs,其在干细胞调节中的关键功能引起了癌症研究的关注。研究表明,长非编码 RNA 在控制发育阶段(如乳腺发育)方面起着至关重要的作用。此外,已经发现 lncRNA 的失调先于包括乳腺癌在内的几种恶性肿瘤的发生。本研究描述了 sncRNAs(包括 miRNAs 和 piRNAs)和 lncRNAs 在乳腺癌的发生和发展中的作用。此外,还讨论了基于各种 ncRNA 的诊断、预后和治疗方法的未来展望。

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