Mandalà Marco, Salerni Lorenzo, Ferretti Fabio, Bindi Ilaria, Gualtieri Giacomo, Corallo Giulia, Viberti Francesca, Gusinu Roberto, Fantino Claudio, Ponzo Silvia, Astore Serena, Boccuzzi Simone, Nuti Daniele
Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy.
University Hospital Le Scotte, Siena, Italy.
Front Neurol. 2023 May 18;14:1177621. doi: 10.3389/fneur.2023.1177621. eCollection 2023.
This study aims to estimate the incidence of Vestibular neuritis (VN) in three different districts in Italy, its epidemiological features, and the prevalence of comorbidities associated with it.
An observational prospective study of 198 patients referred to ENT departments in Siena, Grosseto, and Cuneo was carried out over a 2-year period. Each patient underwent a complete otoneurologic examination in the first 48 h from the onset of symptoms and a brain MRI in the early stages of the disease. The follow-up lasted for 1 year.
The total VN incidence rate of the three municipalities was 48.497 (95% CI: 48.395-48.598) and its standardized value was 53.564 (95% CI: 53.463-53.666). The total VN incidence rate for the whole sample (municipality and district of the three centers) was 18.218 (95% CI: 18.164-18.272), and its standardized value was 20.185 (95% CI: 20.129-20.241). A significant difference was highlighted between patients living in the city compared to those living in the surrounding area ( < 0.000), this may be due to the ease of reaching the otoneurological referral center.
The total incidence rate for the three municipalities was 48.497. This result is higher than previously reported studies.
本研究旨在估计意大利三个不同地区前庭神经炎（VN）的发病率、其流行病学特征以及与之相关的合并症患病率。
对锡耶纳、格罗塞托和库内奥耳鼻喉科转诊的198例患者进行了为期2年的观察性前瞻性研究。每位患者在症状发作后的头48小时内接受了全面的耳神经学检查，并在疾病早期进行了脑部MRI检查。随访持续了1年。
三个城市的VN总发病率为48.497（95%CI：48.395 - 48.598），其标准化值为53.564（95%CI：53.463 - 53.666）。整个样本（三个中心的城市和地区）的VN总发病率为18.218（95%CI：18.164 - 18.272），其标准化值为20.185（95%CI：20.129 - 20.241）。与居住在周边地区的患者相比，居住在城市的患者之间存在显著差异（<0.000），这可能是由于更容易到达耳神经学转诊中心。
三个城市的总发病率为48.497。这一结果高于先前报道的研究。
