内耳蛋白在前庭神经炎中作用的初步研究
Preliminary study of the role of inner ear proteins in vestibular neuritis.
作者信息
Wang Rong, Han Weiwei, Li Li, Li Lulu, Liu Xiaoxia, Wu Yunqin, Fan Weinv
机构信息
Department of Neurology, Ningbo No.2 Hospital, Ningbo, Zhejiang, 315010, PR China.
School of Health Science Center, Ningbo University, Ningbo, Zhejiang, 315211, PR China.
出版信息
J Otol. 2024 Jul;19(3):140-143. doi: 10.1016/j.joto.2024.04.003. Epub 2024 Oct 23.
OBJECTIVE
To evaluate the plasma levels of the otoconial proteins, otoconin-90 and otolin-1, in individuals diagnosed with vestibular neuritis (VN) and determine the feasibility of using these proteins as biomarkers for VN.
METHODS
In this preliminary study, 30 patients diagnosed with VN and 70 healthy individuals were recruited and followed to confirm whether they had benign paroxysmal positional vertigo (BPPV) during the following time. The recorded data included measurements of height, weight, and history of diabetes mellitus or hypertension. Additionally, levels of plasma otoconin-90, and otolin-1 were measured and compared.
RESULTS
The plasma concentrations of otoconin-90 and otolin-1 may not be significantly different between patients with VN and healthy controls, nor among patients with BPPV secondary to VN and patients with VN without BPPV.
CONCLUSIONS
Plasma otoconin-90 and otolin-1 levels may not serve as biomarkers of acute VN episodes or predict BPPV occurrence secondary to VN.
目的
评估被诊断为前庭神经炎（VN）的个体血浆中耳石蛋白、耳石素-90和耳石膜蛋白-1的水平，并确定将这些蛋白用作VN生物标志物的可行性。
方法
在这项初步研究中，招募了30例被诊断为VN的患者和70名健康个体，并对其进行随访，以确认在接下来的时间里他们是否患有良性阵发性位置性眩晕（BPPV）。记录的数据包括身高、体重测量值以及糖尿病或高血压病史。此外，还测量并比较了血浆中耳石素-90和耳石膜蛋白-1的水平。
结果
VN患者与健康对照者之间，以及VN继发BPPV患者与无BPPV的VN患者之间，血浆中耳石素-90和耳石膜蛋白-1的浓度可能无显著差异。
结论
血浆中耳石素-90和耳石膜蛋白-1水平可能无法作为急性VN发作的生物标志物，也无法预测VN继发BPPV的发生。
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