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院前卒中量表机器学习模型预测手术干预的需求。

Prehospital stroke-scale machine-learning model predicts the need for surgical intervention.

机构信息

Department of Neurosurgery, Chiba Municipal Kaihin Hospital, Chiba, Japan.

Department of Neurological Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan.

出版信息

Sci Rep. 2023 Jun 5;13(1):9135. doi: 10.1038/s41598-023-36004-8.

Abstract

While the development of prehospital diagnosis scales has been reported in various regions, we have also developed a scale to predict stroke type using machine learning. In the present study, we aimed to assess for the first time a scale that predicts the need for surgical intervention across stroke types, including subarachnoid haemorrhage and intracerebral haemorrhage. A multicentre retrospective study was conducted within a secondary medical care area. Twenty-three items, including vitals and neurological symptoms, were analysed in adult patients suspected of having a stroke by paramedics. The primary outcome was a binary classification model for predicting surgical intervention based on eXtreme Gradient Boosting (XGBoost). Of the 1143 patients enrolled, 765 (70%) were used as the training cohort, and 378 (30%) were used as the test cohort. The XGBoost model predicted stroke requiring surgical intervention with high accuracy in the test cohort, with an area under the receiver operating characteristic curve of 0.802 (sensitivity 0.748, specificity 0.853). We found that simple survey items, such as the level of consciousness, vital signs, sudden headache, and speech abnormalities were the most significant variables for accurate prediction. This algorithm can be useful for prehospital stroke management, which is crucial for better patient outcomes.

摘要

虽然在不同地区已经报道了院前诊断量表的发展,但我们也开发了一种使用机器学习预测中风类型的量表。在本研究中,我们旨在首次评估一种可预测包括蛛网膜下腔出血和脑出血在内的各种中风类型需要手术干预的量表。在二级医疗保健区域内进行了一项多中心回顾性研究。对由护理人员怀疑患有中风的成年患者进行了包括生命体征和神经症状在内的 23 项分析。主要结局是基于极端梯度提升 (XGBoost) 的手术干预预测的二元分类模型。在纳入的 1143 例患者中,765 例 (70%) 用于训练队列,378 例 (30%) 用于测试队列。XGBoost 模型在测试队列中对需要手术干预的中风具有很高的准确性,受试者工作特征曲线下面积为 0.802(敏感性 0.748,特异性 0.853)。我们发现,意识水平、生命体征、突发头痛和言语异常等简单的调查项目是准确预测的最重要变量。该算法可用于院前中风管理,这对改善患者预后至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee95/10241931/e3142320e150/41598_2023_36004_Fig1_HTML.jpg

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