Int J Oral Maxillofac Implants. 2023;38(3):583-590. doi: 10.11607/jomi.9935.
To compare the osseointegration process of the titanium dental implants with five different surface characteristics-sandblasted, sandblasted and acid-etched, hyaluronic acid-coated (HYA), hydroxyapatite-coated (HA), and machined-in an experimental sheep model at 1- and 3-month examinations.
One hundred sixty dental implants were placed in the left and right tibias of 16 sheep. Five experimental groups were designed. Eight animals (80 implants) were used for biomechanical tests of reverse torque analysis and resonance frequency analysis (RFA). Eight of them (80 implants) were used for the evaluation of bone-to-implant contact (BIC) percentage in histomorphometric analysis. Forty of 80 implants (8 implants for each group) were used at 1-month examinations, and the remaining 40 (8 implants for each group) implants were used at 3-month examinations in the biomechanical test group and histomorphometric examination group, separately.
Intergroup analysis at the 3-month followup showed that the increase in the implant stability quotient (ISQ) value was statistically significant for only the HYA group ( < .05). According to ISQ values at 1 and 3 months, group HYA showed statistically higher values at the 1 and 3-month examinations ( < .05). Groups HYA and HA had statistically higher reverse torque values than other groups at the 1-month examination ( < .05). At the 3-month evaluation, the HYA group showed significantly higher reverse torque values compared to other groups ( < .05). The BIC values of the sandblasted and acid-etched, HYA, and HA groups were significantly higher than the sandblasted and machined groups at the 1- and 3-month examinations ( < .05). The BIC value for the HA group showed decreased value at the 3-month examination compared to the 1-month examination ( < .05).
The RFA, reverse torque, and histomorphometric analysis at 1- and 3-month examinations show that dental implants coated with HYA may have increased potential for osseointegration compared to dental implants with sandblasted, sandblasted and acid-etched, machined, and HA-coated surfaces. Int J Oral Maxillofac Implants 2023;38:583-590. doi: 10.11607/jomi.9935.
在 1 个月和 3 个月的检查中，比较具有五种不同表面特性的钛牙科种植体的骨整合过程：喷砂酸蚀、透明质酸涂层（HYA）、羟基磷灰石涂层（HA）和机械加工。
将 160 个牙科植入物放置在 16 只羊的左右胫骨中。设计了五个实验组。其中 8 只动物（80 个植入物）用于反向扭矩分析和共振频率分析（RFA）的生物力学测试。其中 8 只（每组 80 个植入物）用于组织形态测量分析中骨与种植体接触（BIC）百分比的评估。其中 40 个（每组 8 个植入物）在 1 个月检查时使用，其余 40 个（每组 8 个植入物）在生物力学测试组和组织形态测量检查组中分别在 3 个月检查时使用。
在 3 个月的随访中，组间分析表明，仅 HYA 组的种植体稳定性系数（ISQ）值增加具有统计学意义（<0.05）。根据 1 个月和 3 个月的 ISQ 值，HYA 组在 1 个月和 3 个月的检查中具有统计学上更高的值（<0.05）。在 1 个月检查时，HYA 组和 HA 组的反向扭矩值明显高于其他组（<0.05）。在 3 个月的评估中，与其他组相比，HYA 组的反向扭矩值明显更高（<0.05）。在 1 个月和 3 个月的检查中，喷砂酸蚀、HYA 和 HA 组的 BIC 值明显高于喷砂和机械加工组（<0.05）。HA 组的 BIC 值在 3 个月检查时较 1 个月检查时有所下降（<0.05）。
在 1 个月和 3 个月的 RFA、反向扭矩和组织形态学分析中，与喷砂、喷砂酸蚀、机械加工和 HA 涂层表面的牙科种植体相比，涂有 HYA 的牙科种植体可能具有更高的骨整合潜力。
国际口腔颌面种植学杂志 2023；38：583-590.doi：10.11607/jomi.9935.
