晕动病的组胺能机制。大鼠的神经化学和神经药理学研究。
Histaminergic mechanism of motion sickness. Neurochemical and neuropharmacological studies in rats.
作者信息
Takeda N, Morita M, Kubo T, Yamatodani A, Watanabe T, Wada H, Matsunaga T
出版信息
Acta Otolaryngol. 1986 May-Jun;101(5-6):416-21. doi: 10.3109/00016488609108626.
Rats were rotated about two parallel axes to produce motion sickness, and the histamine levels in their hypothalamus and pons-medulla oblongata were measured. Rotation for 60 min induced kaolin intake, which is a behavioral index of motion sickness in rats, and increased the histamine levels in the hypothalamus and pons-medulla oblongata, the highest levels occurring after 15 min of rotation. In bilaterally labyrinthectomized rats, no rise in histamine level was observed. alpha-Fluoromethylhistidine (alpha-FMH), which depletes the neural component of histamine in the brain, suppressed kaolin intake induced by rotation. These findings demonstrated that the histaminergic neuron system contributes to development of motion sickness, and suggested that alpha-FMH may be effective as an anti-motion sickness drug.
将大鼠绕两个平行轴旋转以诱发晕动病，并测量其下丘脑和脑桥-延髓中的组胺水平。旋转60分钟可诱发高岭土摄取，这是大鼠晕动病的行为指标，并增加了下丘脑和脑桥-延髓中的组胺水平，在旋转15分钟后达到最高水平。在双侧迷路切除的大鼠中，未观察到组胺水平升高。α-氟甲基组氨酸（α-FMH）可耗尽脑中组胺的神经成分，抑制旋转诱发的高岭土摄取。这些发现表明组胺能神经元系统参与晕动病的发生，并提示α-FMH可能作为一种抗晕动病药物有效。
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