Morita M, Takeda N, Hasegawa S, Yamatodani A, Wada H, Sakai S, Kubo T, Matsunaga T
Department of Otolaryngology, Osaka University School of Medicine, Japan.
Acta Otolaryngol. 1990 Sep-Oct;110(3-4):196-202. doi: 10.3109/00016489009122537.
The effects of the anti-cholinergic drug scopolamine, an anti-motion sickness drug, and of the cholinergics physostigmine and neostigmine on habituation to motion sickness in rats were examined using pica, measured as eating of kaolin, as a behavioural index of motion sickness in rats. Rats were rotated around two axes for 1 h once a day for 10 or 11 days. Rotation-induced kaolin intake of control rats gradually decreased from day 9 of daily rotation. Test rats were not treated for the first 3 days, given drugs on days 4-7 of rotation and then again given no drugs for the next 3 or 4 days. Rotation-induced kaolin intake of test rats was compared to that of controls. Results showed that TTS (Transdermal Therapeutic System)-scopolamine administration facilitated habituation to rotation, whereas physostigmine, a centrally acting cholinesterase inhibitor, suppressed it, and neostigmine, a peripherally active cholinesterase inhibitor, had no effect on habituation at all. These findings suggest that the central cholinergic neuron system plays an important role in the neural mechanism of habituation to motion in rats.
抗胆碱能药物东莨菪碱（一种抗晕动病药物）以及胆碱能药物毒扁豆碱和新斯的明对大鼠晕动病适应性的影响，通过将食土癖（以高岭土摄入量衡量）作为大鼠晕动病的行为指标来进行研究。大鼠每天绕两个轴旋转1小时，持续10或11天。从每日旋转的第9天起，对照大鼠因旋转引起的高岭土摄入量逐渐减少。试验大鼠在前3天不进行处理，在旋转的第4 - 7天给予药物，然后在接下来的3或4天再次不给予药物。将试验大鼠因旋转引起的高岭土摄入量与对照大鼠的进行比较。结果显示，经皮给药系统（TTS） - 东莨菪碱促进了对旋转的适应性，而中枢作用的胆碱酯酶抑制剂毒扁豆碱抑制了这种适应性，外周活性的胆碱酯酶抑制剂新斯的明对适应性则完全没有影响。这些发现表明，中枢胆碱能神经元系统在大鼠对运动的适应性神经机制中起重要作用。
