IBIS (Universidad de Sevilla, HUVR, Junta de Andalucia, CSIC), Sevilla, Spain.
Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
Transl Psychiatry. 2023 Jun 6;13(1):189. doi: 10.1038/s41398-023-02482-7.
Despite the high contagion and mortality rates that have accompanied the coronavirus disease-19 (COVID-19) pandemic, the clinical presentation of the syndrome varies greatly from one individual to another. Potential host factors that accompany greater risk from COVID-19 have been sought and schizophrenia (SCZ) patients seem to present more severe COVID-19 than control counterparts, with certain gene expression similarities between psychiatric and COVID-19 patients reported. We used summary statistics from the last SCZ, bipolar disorder (BD), and depression (DEP) meta-analyses available on the Psychiatric Genomics Consortium webpage to calculate polygenic risk scores (PRSs) for a target sample of 11,977 COVID-19 cases and 5943 subjects with unknown COVID-19 status. Linkage disequilibrium score (LDSC) regression analysis was performed when positive associations were obtained from the PRS analysis. The SCZ PRS was a significant predictor in the case/control, symptomatic/asymptomatic, and hospitalization/no hospitalization analyses in the total and female samples; and of symptomatic/asymptomatic status in men. No significant associations were found for the BD or DEP PRS or in the LDSC regression analysis. SNP-based genetic risk for SCZ, but not for BD or DEP, may be associated with higher risk of SARS-CoV-2 infection and COVID-19 severity, especially among women; however, predictive accuracy barely exceeded chance level. We believe that the inclusion of sexual loci and rare variations in the analysis of genomic overlap between SCZ and COVID-19 will help to elucidate the genetic commonalities between these conditions.
尽管伴随 2019 冠状病毒病（COVID-19）大流行的冠状病毒具有高传染性和高死亡率，但该综合征的临床表现个体间差异很大。人们一直在寻找与 COVID-19 相关的潜在宿主因素，而精神分裂症（SCZ）患者似乎比对照患者表现出更严重的 COVID-19，据报道，精神科患者和 COVID-19 患者之间存在某些基因表达相似性。我们使用精神疾病基因组学联合会网页上提供的最后一次 SCZ、双相情感障碍（BD）和抑郁（DEP）荟萃分析的汇总统计数据，为 11977 例 COVID-19 病例和 5943 例 COVID-19 状态未知的对照样本计算多基因风险评分（PRS）。当 PRS 分析获得阳性关联时，进行连锁不平衡评分（LDSC）回归分析。在总样本和女性样本中，SCZ PRS 是病例/对照、有症状/无症状和住院/不住院分析的显著预测因子；在男性中，SCZ PRS 是有症状/无症状状态的显著预测因子。BD 或 DEP PRS 或 LDSC 回归分析均未发现显著关联。SNP 遗传风险与 SCZ 相关，但与 BD 或 DEP 无关，可能与 SARS-CoV-2 感染和 COVID-19 严重程度的风险增加相关，尤其是在女性中；然而，预测准确性几乎未超过机会水平。我们认为，在分析 SCZ 和 COVID-19 之间的基因组重叠时纳入性基因座和罕见变异，将有助于阐明这两种情况之间的遗传共性。
