Monistrol-Mula Anna, Felez-Nobrega Mireia, Byrne Enda M, Lind Penelope A, Hickie Ian B, Martin Nicholas G, Medland Sarah E, Colodro-Conde Lucía, Mitchell Brittany L
Group of Epidemiology of Psychiatric disorders and Ageing, Sant Joan de Déu Research Institute, Sant Boi de Llobregat, Barcelona, Spain.
Centre for Biomedical Research on Mental Health (CIBERSAM), Madrid, Spain.
Psychol Med. 2024 Nov 18;54(15):1-10. doi: 10.1017/S0033291724001983.
Genetic vulnerability to mental disorders has been associated with coronavirus disease-19 (COVID-19) outcomes. We explored whether polygenic risk scores (PRSs) for several mental disorders predicted poorer clinical and psychological COVID-19 outcomes in people with pre-existing depression.
Data from three assessments of the Australian Genetics of Depression Study ( = 4405; 52.2 years ± 14.9; 76.2% females) were analyzed. Outcomes included COVID-19 clinical outcomes (severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] infection and long COVID, noting the low incidence of COVID-19 cases in Australia at that time) and COVID-19 psychological outcomes (COVID-related stress and COVID-19 burnout). Predictors included PRS for depression, bipolar disorder, schizophrenia, and anxiety. The associations between these PRSs and the outcomes were assessed with adjusted linear/logistic/multinomial regressions. Mediation ( = 4338) and moderation ( = 3326) analyses were performed to explore the potential influence of anxiety symptoms and resilience on the identified associations between the PRSs and COVID-19 psychological outcomes.
None of the selected PRS predicted SARS-CoV-2 infection or long COVID. In contrast, the depression PRS predicted higher levels of COVID-19 burnout. Anxiety symptoms fully mediated the association between the depression PRS and COVID-19 burnout. Resilience did not moderate this association.
A higher genetic risk for depression predicted higher COVID-19 burnout and this association was fully mediated by anxiety symptoms. Interventions targeting anxiety symptoms may be effective in mitigating the psychological effects of a pandemic among people with depression.
精神障碍的遗传易感性与冠状病毒病19（COVID-19）的预后相关。我们探讨了几种精神障碍的多基因风险评分（PRS）是否能预测已有抑郁症患者较差的COVID-19临床和心理预后。
对澳大利亚抑郁症遗传学研究的三次评估数据（n = 4405；52.2岁±14.9；76.2%为女性）进行了分析。结局包括COVID-19临床结局（严重急性呼吸综合征冠状病毒2[SARS-CoV-2]感染和新冠后症状，当时澳大利亚COVID-19病例发病率较低）和COVID-19心理结局（COVID相关应激和COVID-19倦怠）。预测因素包括抑郁症、双相情感障碍、精神分裂症和焦虑症的PRS。通过调整后的线性/逻辑/多项回归评估这些PRS与结局之间的关联。进行了中介分析（n = 4338）和调节分析（n = 3326），以探讨焦虑症状和心理韧性对所确定的PRS与COVID-19心理结局之间关联的潜在影响。
所选的PRS均未预测SARS-CoV-2感染或新冠后症状。相比之下，抑郁症PRS预测了更高水平的COVID-19倦怠。焦虑症状完全介导了抑郁症PRS与COVID-19倦怠之间的关联。心理韧性并未调节这种关联。
较高的抑郁症遗传风险预测了更高的COVID-19倦怠，这种关联完全由焦虑症状介导。针对焦虑症状的干预措施可能有效地减轻大流行对抑郁症患者的心理影响。
