Huang Ju, Zhu Yu, Xiao Hang, Liu Jingwen, Li Songtao, Zheng Qiao, Tang Jianyuan, Meng Xiangrui
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People's Republic of China.
Capital Medical University, Beijing, People's Republic of China.
Chin Med. 2023 Jun 6;18(1):66. doi: 10.1186/s13020-023-00764-2.
Traditional Chinese medicine (TCM) has been used for centuries to prevent and treat a variety of illnesses, and its popularity is increasing worldwide. However, the clinical applications of natural active components in TCM are hindered by the poor solubility and low bioavailability of these compounds. To address these issues, Chinese medicine self-assembly nanostrategy (CSAN) is being developed. Many active components of TCM possess self-assembly properties, allowing them to form nanoparticles (NPs) through various noncovalent forces. Self-assembled NPs (SANs) are also present in TCM decoctions, and they are closely linked to the therapeutic effects of these remedies. SAN is gaining popularity in the nano research field due to its simplicity, eco-friendliness, and enhanced biodegradability and biocompatibility compared to traditional nano preparation methods. The self-assembly of active ingredients from TCM that exhibit antitumour effects or are combined with other antitumour drugs has generated considerable interest in the field of cancer therapeutics. This paper provides a review of the principles and forms of CSAN, as well as an overview of recent reports on TCM that can be used for self-assembly. Additionally, the application of CSAN in various cancer diseases is summarized, and finally, a concluding summary and thoughts are proposed. We strongly believe that CSAN has the potential to offer fresh strategies and perspectives for the modernization of TCM.
中药已被用于预防和治疗各种疾病数百年，并且在全球范围内其受欢迎程度正在上升。然而，中药中天然活性成分的临床应用受到这些化合物溶解度差和生物利用度低的阻碍。为了解决这些问题，正在开发中药自组装纳米策略（CSAN）。许多中药活性成分具有自组装特性，使它们能够通过各种非共价力形成纳米颗粒（NPs）。自组装纳米颗粒（SANs）也存在于中药汤剂中，并且它们与这些药物的治疗效果密切相关。与传统纳米制备方法相比，SAN由于其简单性、生态友好性以及增强的生物降解性和生物相容性，在纳米研究领域越来越受欢迎。来自中药的具有抗肿瘤作用或与其他抗肿瘤药物联合的活性成分的自组装在癌症治疗领域引起了相当大的兴趣。本文综述了CSAN的原理和形式，以及关于可用于自组装的中药的近期报道概述。此外，总结了CSAN在各种癌症疾病中的应用，最后提出了总结和思考。我们坚信CSAN有潜力为中药现代化提供新的策略和视角。
