食用新开发的合生元酸奶对患有代谢综合征的成年人的代谢综合征组分、氧化应激状态及其他一些心血管疾病危险因素的影响：一项随机临床试验的研究方案
The effect of a new developed synbiotic yogurt consumption on metabolic syndrome components, oxidative stress status, and some other cardiovascular disease risk factors in adults with metabolic syndrome: a study protocol for a randomized clinical trial.
作者信息
Zolghadrpour Mohammad-Amin, Karimpour Farzad, Jowshan Mohammad-Reza, Imani Hossein, Asghari Somayyeh
机构信息
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, No#44, Hojjatdoust St., Naderi St., Keshavarz Blvd, Tehran, 141556117, Iran.
Social Determinants of Health Research Center, Yasuj University of Medical Science, Yasuj, Iran.
出版信息
BMC Nutr. 2023 Jun 6;9(1):68. doi: 10.1186/s40795-023-00723-y.
BACKGROUND
Metabolic syndrome is recognized as one of the most common global health issues, which may cause numerous side effects. Studies have shown the favorable effects of probiotic supplements on glycemic indices, lipid profiles, and oxidative stress status. However, the number of studies investigating the effects of food products containing probiotics and prebiotics on metabolic diseases is limited. Limited evidence also shows that products containing Lactobacillus plantarum could affect metabolic alterations in chronic diseases. No previous study evaluated the impact of synbiotic yogurt containing Lactobacillus plantarum on people with metabolic syndrome. Therefore, the current study aims to investigate the effect of the newly developed synbiotic yogurt containing Lactobacillus plantarum, Lactobacillus pentosus, and Chloromyces marcosianos yeast on the components of metabolic syndrome, oxidative stress status, and some other risk factors for cardiovascular diseases in adults with metabolic syndrome.
METHODS
In this study, 44 patients with metabolic syndrome will be randomly assigned to intervention and control groups in a randomized, double-blind, controlled clinical trial. Participants in the intervention group will consume 300 g of synbiotic yogurt daily, while those in the control group will consume 300 g of regular yogurt daily for 12 weeks. Anthropometric measurements, blood pressure, and biochemical parameters will be evaluated before and after the intervention.
DISCUSSION
The management of the metabolic syndrome presents significant clinical challenges. While probiotic supplementation for these individuals has been considered, the consumption of probiotic-rich foods has received considerably less attention.
TRIAL REGISTRATION NUMBER
Iranian Registry of Clinical Trials (IRCT20220426054667N1) (2022-05-18).
背景
代谢综合征被认为是全球最常见的健康问题之一，可能会引发多种副作用。研究表明，补充益生菌对血糖指数、血脂水平和氧化应激状态具有有益影响。然而，研究含有益生菌和益生元的食品对代谢性疾病影响的研究数量有限。有限的证据还表明，含有植物乳杆菌的产品可能会影响慢性病的代谢改变。此前尚无研究评估含有植物乳杆菌的合生元酸奶对代谢综合征患者的影响。因此，本研究旨在调查新开发的含有植物乳杆菌、戊糖乳杆菌和马克斯克鲁维酵母的合生元酸奶对患有代谢综合征的成年人的代谢综合征组成成分、氧化应激状态以及其他一些心血管疾病风险因素的影响。
方法
在本研究中，44名代谢综合征患者将在一项随机、双盲、对照临床试验中被随机分配至干预组和对照组。干预组的参与者每天将食用300克合生元酸奶，而对照组的参与者每天将食用300克普通酸奶，持续12周。在干预前后将评估人体测量指标、血压和生化参数。
讨论
代谢综合征的管理面临重大临床挑战。虽然已经考虑为这些个体补充益生菌，但富含益生菌的食物的消费受到的关注要少得多。
试验注册号
伊朗临床试验注册中心（IRCT20220426054667N1）（2022年5月18日）。
Zotero 插件