氢化可的松对衰老大鼠肝脏和大脑中苹果酸脱氢酶同工酶的差异调节：（苹果酸脱氢酶同工酶/衰老/氢化可的松）

Differential Regulation of Malate Dehydrogenase Isoenzymes by Hydrocortisone in the Liver and Brain of Aging Rats: (MDH isoenzymes/aging/hydrocortisone).

作者信息

Sharma Ramesh, Patnaik Swaraj K

机构信息

Biochemistry Laboratory, Department of Zoology University of Delhi, Delhi 110007, India.

出版信息

Dev Growth Differ. 1982;24(5):501-505. doi: 10.1111/j.1440-169X.1982.00501.x.

DOI:10.1111/j.1440-169X.1982.00501.x

PMID:37281291

Abstract

The activities and induction patterns of the isoenzymes of malate dehydrogenase (MDH) of the liver and brain of male rats of various ages were studied. The activities of both the isoenzymes of MDH of the liver and brain show a gradual increase with increasing age of the rats. Adrenalectomy decreases and hydrocortisone treatment increases the activity of cytoplasmic MDH of the liver and brain of rats of all the ages except that of the brain isoenzyme of old rats. This hormone-mediated induction of the isoenzyme is actinomycin D-sensitive. Furthermore, adrenalectomy decreases and hydrocortisone treatment increases the activity of mitochondrial MDH of the liver of young and adult rats but not in old rats. However, these treatments do not show any significant effect on the activity of mitochondrial MDH of the brain of rats of all the ages.

摘要

研究了不同年龄雄性大鼠肝脏和大脑中苹果酸脱氢酶（MDH）同工酶的活性及诱导模式。肝脏和大脑中MDH同工酶的活性均随大鼠年龄增长而逐渐增加。肾上腺切除会降低，而氢化可的松处理会增加各年龄段大鼠肝脏和大脑细胞质MDH的活性，但老龄大鼠大脑同工酶除外。这种激素介导的同工酶诱导对放线菌素D敏感。此外，肾上腺切除会降低，而氢化可的松处理会增加幼年和成年大鼠肝脏线粒体MDH的活性，但老龄大鼠无此现象。然而，这些处理对各年龄段大鼠大脑线粒体MDH的活性均无显著影响。