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Wrapping up the role of pericytes in Parkinson's disease.

作者信息

Stevenson Taylor John, Dieriks Birger Victor

机构信息

Department of Pharmacology, University of Auckland; Centre for Brain Research, University of Auckland, Auckland, New Zealand.

Centre for Brain Research; Department of Anatomy and Medical Imaging, University of Auckland, Auckland, New Zealand.

出版信息

Neural Regen Res. 2023 Nov;18(11):2395-2396. doi: 10.4103/1673-5374.371362.

DOI:10.4103/1673-5374.371362
PMID:37282465
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10360080/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f43/10360080/0df2ac7c9917/NRR-18-2395-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f43/10360080/0df2ac7c9917/NRR-18-2395-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1f43/10360080/0df2ac7c9917/NRR-18-2395-g001.jpg

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本文引用的文献

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Aging and aging-related diseases: from molecular mechanisms to interventions and treatments.衰老和与衰老相关的疾病：从分子机制到干预和治疗。
Signal Transduct Target Ther. 2022 Dec 16;7(1):391. doi: 10.1038/s41392-022-01251-0.
2
Multiple system atrophy: α-Synuclein strains at the neuron-oligodendrocyte crossroad.多系统萎缩：α-突触核蛋白在神经元-少突胶质细胞交叉路口的聚集。
Mol Neurodegener. 2022 Nov 26;17(1):77. doi: 10.1186/s13024-022-00579-z.
3
Human pericytes degrade diverse α-synuclein aggregates.人周细胞降解多种α-突触核蛋白聚集物。
PLoS One. 2022 Nov 18;17(11):e0277658. doi: 10.1371/journal.pone.0277658. eCollection 2022.
4
Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders.在路易体疾病中揭示了具有独特翻译后修饰特征的突出星形胶质细胞 alpha-突触核蛋白病理学。
Acta Neuropathol Commun. 2022 Nov 12;10(1):163. doi: 10.1186/s40478-022-01468-8.
5
Pericytes take up and degrade α-synuclein but succumb to apoptosis under cellular stress.周细胞摄取并降解α-突触核蛋白，但在细胞应激下会凋亡。
Sci Rep. 2022 Oct 15;12(1):17314. doi: 10.1038/s41598-022-20261-0.
6
C-terminal truncation modulates α-Synuclein's cytotoxicity and aggregation by promoting the interactions with membrane and chaperone.C 端截断通过促进与膜和伴侣蛋白的相互作用来调节 α-突触核蛋白的细胞毒性和聚集。
Commun Biol. 2022 Aug 9;5(1):798. doi: 10.1038/s42003-022-03768-0.
7
Human α-synuclein overexpression in a mouse model of Parkinson's disease leads to vascular pathology, blood brain barrier leakage and pericyte activation.人类α-突触核蛋白在帕金森病小鼠模型中的过表达导致血管病变、血脑屏障渗漏和周细胞激活。
Sci Rep. 2021 Jan 13;11(1):1120. doi: 10.1038/s41598-020-80889-8.
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The emerging role of α-synuclein truncation in aggregation and disease.α-突触核蛋白截短在聚集和疾病中的新兴作用。
J Biol Chem. 2020 Jul 24;295(30):10224-10244. doi: 10.1074/jbc.REV120.011743. Epub 2020 May 18.
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