Toto-Moukouo J J, Achimastos A, Asmar R G, Hugues C J, Safar M E
Am Heart J. 1986 Jul;112(1):136-40. doi: 10.1016/0002-8703(86)90691-5.
Pulse wave velocity was measured in 27 obese and 25 nonobese patients with sustained essential hypertension. Pulse wave velocity was significantly increased in obese patients in comparison with nonobese patients. The result was independent of age, sex, and level of blood pressure. In the overall population, a significant positive correlation (r = 0.85; p less than 0.001) was observed between the degree of obesity and pulse wave velocity. A study of partial correlation coefficients indicated that the levels of glycemia, cholesterolemia, and triglyceridemia did not influence the relationship. After body weight was reduced, blood pressure decreased and arterial compliance increased. The results show that in patients with sustained essential hypertension: pulse wave velocity and obesity are strongly related independent of age, sex, blood pressure, and associated metabolic disorders and body weight reduction is associated with an improvement of arterial distensibility and compliance.
对27名肥胖和25名非肥胖的持续性原发性高血压患者测量了脉搏波速度。与非肥胖患者相比，肥胖患者的脉搏波速度显著增加。该结果与年龄、性别和血压水平无关。在总体人群中，观察到肥胖程度与脉搏波速度之间存在显著正相关（r = 0.85；p < 0.001）。偏相关系数研究表明，血糖、胆固醇血症和甘油三酯血症水平不影响这种关系。体重减轻后，血压下降，动脉顺应性增加。结果表明，在持续性原发性高血压患者中：脉搏波速度与肥胖密切相关，与年龄、性别、血压及相关代谢紊乱无关，体重减轻与动脉扩张性和顺应性的改善有关。
