RoboCap：用于增强胃肠道药物输送的机器人黏液清除胶囊。
RoboCap: Robotic mucus-clearing capsule for enhanced drug delivery in the gastrointestinal tract.
机构信息
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Sci Robot. 2022 Sep 28;7(70):eabp9066. doi: 10.1126/scirobotics.abp9066.
Oral drug delivery of proteins is limited by the degradative environment of the gastrointestinal tract and poor absorption, requiring parenteral administration of these drugs. Luminal mucus represents the initial steric and dynamic barrier to absorption. To overcome this barrier, we report the development of the RoboCap, an orally ingestible, robotic drug delivery capsule that locally clears the mucus layer, enhances luminal mixing, and topically deposits the drug payload in the small intestine to enhance drug absorption. RoboCap's mucus-clearing and churning movements are facilitated by an internal motor and by surface features that interact with small intestinal plicae circulares, villi, and mucus. Vancomycin (1.4 kilodaltons of glycopeptide) and insulin (5.8 kilodaltons of peptide) delivery mediated by RoboCap resulted in enhanced bioavailability 20- to 40-fold greater in ex vivo and in vivo swine models when compared with standard oral delivery ( < 0.05). Further, insulin delivery via the RoboCap resulted in therapeutic hypoglycemia, supporting its potential to facilitate oral delivery of drugs that are normally precluded by absorption limitations.
蛋白质的口服给药受到胃肠道降解环境和吸收不良的限制，需要这些药物的肠胃外给药。腔粘液代表了吸收的初始空间和动力障碍。为了克服这一障碍，我们开发了 RoboCap，这是一种可口服的、机器人驱动的药物输送胶囊，可局部清除粘液层，增强腔内混合，并将药物有效载荷局部递送至小肠以增强药物吸收。RoboCap 的粘液清除和搅拌运动由内部电机和与小肠环形皱襞、绒毛和粘液相互作用的表面特征来辅助。与标准口服给药相比，RoboCap 介导的万古霉素（1.4 千道尔顿糖肽）和胰岛素（5.8 千道尔顿肽）的输送使生物利用度提高了 20-40 倍（<0.05）。此外，通过 RoboCap 输送胰岛素可实现治疗性低血糖，这支持了其促进通常因吸收限制而无法口服给药的药物的潜力。
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