Zhang Qian, Han Zhu-Zhen, Gu Li-Hua, Wang Zheng-Tao
MOE Key Laboratory for Standardization of Chinese Medicines, SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China Shanghai R&D Center for Standardization of Chinese Medicines Shanghai 201203, China.
Zhongguo Zhong Yao Za Zhi. 2023 Apr;48(8):2041-2058. doi: 10.19540/j.cnki.cjcmm.20221115.201.
Glechomae Herba, the dried aerial part of Glechoma longituba(Labiatae), has the effects of promoting urination, draining dampness, and relieving stranguria. It has received wide attention in recent years owing to the satisfactory efficacy on lithiasis. Amid the in-depth chemical and pharmacological research, it has been found that Glechomae Herba has antibacterial, anti-inflammatory, antioxidant, antithrombotic, hepatoprotective, cholagogic, antitumor, hypoglycemic, and lipid-lowering effects. The main chemical constituents are volatile oils, flavonoids, terpenoids, phenylpropanoids, and organic acids. This paper summarized the chemical constituents and pharmacological effects of Glechomae Herba. Based on genetic relationship of plants, the characteristics, efficacy, and pharmacokinetics of the chemical constituents, and the potential of these constituents as quality markers(Q-markers), it was summed up that ursolic acid, caffeic acid, rosmarinic acid, luteolin-7-O-diglucuronide, apigenin, apigenin-7-O-diglucuronide, apigetrin, and glechone can be the candidate Q-markers of Glechomae Herba.
金钱草为唇形科植物活血丹的干燥地上部分，具有利尿、利湿、通淋的功效。近年来因其对结石病疗效显著而备受关注。在深入的化学和药理学研究中，发现金钱草具有抗菌、抗炎、抗氧化、抗血栓、保肝、利胆、抗肿瘤、降血糖和降脂作用。其主要化学成分有挥发油、黄酮类、萜类、苯丙素类和有机酸类。本文综述了金钱草的化学成分和药理作用。基于植物亲缘关系、化学成分的特性、功效、药代动力学以及这些成分作为质量标志物（Q-标志物）的潜力，总结出熊果酸、咖啡酸、迷迭香酸、木犀草素-7-O-二葡萄糖醛酸苷、芹菜素、芹菜素-7-O-二葡萄糖醛酸苷、芹菜苷元和活血丹酮可作为金钱草的候选Q-标志物。
