Yang Xuan, Li Jun-Ying, Shan Xiao-Xiao, Huang Peng, Peng Can, Zhang Cai-Yun
Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application Hefei 230012, China Engineering Technology Research Center of Modernized Pharmaceutics, Anhui Education Department (AUCM) Hefei 230012, China School of Pharmacy, Anhui University of Chinese Medicine Hefei 230012, China Anhui Genuine Chinese Medicinal Materials Quality Improvement Innovation Collaborative Center Hefei 230012, China Institute of Pharmaceutics, Anhui Academy of Chinese Medicine Hefei 230012, China.
Zhongguo Zhong Yao Za Zhi. 2023 Apr;48(8):2077-2085. doi: 10.19540/j.cnki.cjcmm.20220919.201.
Kaixin Powder is a classic prescription for invigorating Qi, nourishing the mind, and calming the mind. It has pharmacological effects of improving learning and memory ability, resisting oxidation, delaying aging, and promoting the differentiation and regeneration of nerve cells. It is mainly used in the modern clinical treatment of amnesia, depression, dementia, and other diseases. The present paper reviewed the research progress on the chemical composition and pharmacological action of Kaixin Powder, predicted and analyzed its quality markers(Q-markers) according to the concept of Chinese medicine Q-markers, including transmission and traceability, specificity, effectiveness, measurability, and compound compatibility environment. The results suggested that sibiricose A5, sibiricose A6, polygalaxanthone Ⅲ, 3',6-disinapoylsucrose, tenuifoliside A, ginsenoside Rg_1, ginsenoside Re, ginsenoside Rb_1, pachymic acid, β-asarone, and α-asarone could be used as Q-markers of Kaixin Powder. This study is expected to provide a scientific basis for establishing the quality control system and the whole process quality traceability system of Kaixin Powder compound preparations.
开心散是益气养心、安神定志的经典方剂。具有改善学习记忆能力、抗氧化、延缓衰老、促进神经细胞分化与再生等药理作用。现代临床主要用于治疗健忘、抑郁、痴呆等疾病。本文综述了开心散化学成分及药理作用的研究进展，并根据中药质量标志物的概念对其质量标志物（Q-标志物）进行了预测分析，包括传递与溯源性、特异性、有效性、可测性及复方配伍环境。结果表明，西伯利亚远志糖A5、西伯利亚远志糖A6、多花黄精三醇、3'，6-二芥子酰蔗糖、细叶远志苷A、人参皂苷Rg_1、人参皂苷Re、人参皂苷Rb_1、茯苓酸、β-细辛醚和α-细辛醚可作为开心散的Q-标志物。本研究有望为建立开心散复方制剂的质量控制体系及全过程质量追溯体系提供科学依据。
