Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, Research Unit of PK-PD Based Bioactive Components and Pharmacodynamic Target Discovery of Natural Medicine of Chinese Academy of Medical Sciences, China Pharmaceutical University, Nanjing 210009, China.
Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics, Research Unit of PK-PD Based Bioactive Components and Pharmacodynamic Target Discovery of Natural Medicine of Chinese Academy of Medical Sciences, China Pharmaceutical University, Nanjing 210009, China.
Chin J Nat Med. 2023 Sep;21(9):658-669. doi: 10.1016/S1875-5364(23)60400-5.
Pien Tze Huang (PTH) was documented as an imperial prescription composed of Notoginseng Radix, Calculus Bovis, Snake Gallbladder, and Musk. It is famous in China and Asian countries due to its excellent effects in heat clearing, detoxifying, swelling reduction, and pain relieving. Modern pharmacological studies demonstrate that PTH shows excellent effects against various inflammatory diseases, liver diseases, and cancers. This review summaries the pharmacological effects, clinical applications, and mainchemical components of PTH. More importantly, its potential quality markers (Q-markers) were then analyzed based on the "five principles" of Q-markers under the guidance of Traditional Chinese Medicine theory, including transfer and traceability, specificity, efficacy, compatibility, and measurability. As a result, ginsenosides Rb1, ginsenoside Rg1, ginsenoside Rd, ginsenoside Re, notoginsenoside R1, dencichine, bilirubin, biliverdin, taurocholic acid, and muscone are considered as the Q-markers of PTH. These findings will provide guidance and assistance for the construction of a quality control system for PTH.
片仔癀（PTH）被记载为一种由三七、牛黄、蛇胆和麝香组成的宫廷秘方。由于其在清热、解毒、消肿和止痛方面的卓越效果，它在中国和亚洲国家享有盛誉。现代药理学研究表明，PTH 对各种炎症性疾病、肝病和癌症均具有显著疗效。本综述总结了 PTH 的药理学作用、临床应用和主要化学成分。更重要的是，基于中药理论指导下的 Q 标志物“五原则”，分析了其潜在的质量标志物（Q 标志物），包括转移和可追溯性、特异性、功效、兼容性和可测量性。因此，人参皂苷 Rb1、人参皂苷 Rg1、人参皂苷 Rd、人参皂苷 Re、三七皂苷 R1、丹酚酸 B、胆红素、胆绿素、牛磺胆酸和麝香酮被认为是 PTH 的 Q 标志物。这些发现将为 PTH 质量控制系统的构建提供指导和帮助。
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