Wang Yu, Yang Xue, Xia Peng-Fei, Ma Xiao, Yang Rui-Jing, Wang Yu-Xia, Fan Qin, Zhao Lei
Gansu University of Chinese Medicine Lanzhou 730000, China.
Gansu University of Chinese Medicine Lanzhou 730000, China Key Laboratory of Chemistry and Quality for Traditional Chinese Medicines of the College of Gansu Province, Gansu University of Chinese Medicine Lanzhou 730000, China Gansu Province Engineering Laboratory for Traditional Chinese Medicines Standardization Technology and Popularization Lanzhou 730000, China.
Zhongguo Zhong Yao Za Zhi. 2020 Jun;45(12):2765-2771. doi: 10.19540/j.cnki.cjcmm.20190812.201.
Suanzaoren Decoction is a classic prescription for nourishing the heart and liver, nourishing blood and tranquilizing the mind. It has the functions of sedation and hypnosis, anti-anxiety, anti-depression, anti-convulsion and so on. Modern clinic is mostly used to treat different types of insomnia, depression, neurasthenia, tension headache and vertigo. In this paper, the chemical consti-tuents, pharmacological effects and clinical application of Suanzaoren Decoction are reviewed. Based on this, the quality marker(Q-marker) of Suanzaoren Decoction was predicted and analyzed according to the "five principles" of Q-marker of traditional Chinese medicine--transmission and traceability, specificity, effectiveness, measurability and compatibility environment of compound prescriptions. The results indicated that jujuboside, spinosin, ferulic acid, senkyunolide Ⅰ, sarsasapogenin, mangiferin, liquiritoside and glycyrrhizic acid were predicted and analyzed, and those can be used as Q-markers of Suanzaoren Decoction. Subsequently, the above components can be selected as indicators to control and evaluate the quality of Suanzaoren Decoction and its preparations, and establish a quality traceability system.
酸枣仁汤是养心安神、养血柔肝的经典方剂。具有镇静催眠、抗焦虑、抗抑郁、抗惊厥等作用。现代临床多用于治疗各类失眠、抑郁、神经衰弱、紧张性头痛及眩晕等。本文对酸枣仁汤的化学成分、药理作用及临床应用进行综述。在此基础上，依据中药质量标志物（Q-标志物）的“五原则”——传递与溯源性、特异性、有效性、可测性及复方配伍环境，对酸枣仁汤的质量标志物进行预测分析。结果表明，酸枣仁皂苷、斯皮诺素、阿魏酸、藁本内酯Ⅰ、知母皂苷元、芒果苷、甘草苷及甘草酸被预测分析，可作为酸枣仁汤的Q-标志物。随后，可选取上述成分作为指标来控制和评价酸枣仁汤及其制剂的质量，并建立质量追溯体系。
