Wu Yuan-Ning, Sun Biao, Wang Jun-Ya, Wang De-Zhi, Song Min, Zhang Xiao-Qi
Guangdong Engineering Research Center for Modernization of Traditional Chinese Medicine, Jinan University Guangzhou 510632, China.
Guangdong Engineering Research Center for Modernization of Traditional Chinese Medicine, Jinan University Guangzhou 510632, China NMPA Key Laboratory for Quality Evaluation of Traditional Chinese Medicine,Jinan University Guangzhou 510632, China.
Zhongguo Zhong Yao Za Zhi. 2023 Apr;48(7):1885-1891. doi: 10.19540/j.cnki.cjcmm.20221231.201.
To study the chemical constituents from the stems and leaves of Humulus scandens, this study isolated thirteen compounds by different chromatographic methods including silica gel column, ODS, Sephadex LH-20 and preparative HPLC. Based on comprehensive analysis, the chemical structures were elucidated and identified as citrunohin A(1), chrysosplenetin(2), casticin(3), neoechinulin A(4), ethyl 1H-indole-3-carboxylate(5), 3-hydroxyacetyl-indole(6),(1H-indol-3-yl) oxoacetamide(7), inonotusic acid(8), arteannuin B(9), xanthotoxol(10), α-tocopherol quinone(11), eicosanyl-trans-p-coumarate(12), and 9-oxo-(10E,12E)-octadecadienoic acid(13). Among them, compound 1 was a new dihydrochalcone, and the other compounds were obtained from H. scandens for the first time.
为研究葎草茎和叶中的化学成分,本研究采用硅胶柱色谱、ODS柱色谱、葡聚糖凝胶LH - 20柱色谱及制备型高效液相色谱等不同色谱方法分离得到13个化合物。经综合分析,阐明并鉴定了这些化合物的化学结构,分别为瓜楼新苷A(1)、金腰乙素(2)、紫花牡荆素(3)、新刺囊菌素A(4)、1H - 吲哚 - 3 - 羧酸乙酯(5)、3 - 羟基乙酰基吲哚(6)、(1H - 吲哚 - 3 - 基)草酰乙酰胺(7)、印度地衣酸(8)、青蒿琥酯(9)、花椒毒素(10)、α - 生育酚醌(11)、二十烷基反式对香豆酸(12)和9 - 氧代 -(10E,12E)- 十八碳二烯酸(13)。其中,化合物1为新的二氢查耳酮,其他化合物均为首次从葎草中获得。