1,3-二取代立方烷衍生物的实用合成。
A practical synthesis of 1,3-disubstituted cubane derivatives.
机构信息
Department of Chemistry, Lancaster University, Bailrigg, LA1 4YB, UK.
Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, UK.
出版信息
Chem Commun (Camb). 2023 Jun 22;59(51):7971-7973. doi: 10.1039/d3cc02164e.
A robust multigram-scale synthesis of 1,3-disubstituted cubanes (previously only available on milligram-scale) is reported. The approach exploits a readily available enone intermediate previously used for the synthesis of 1,4-disubstituted cubanes, by introducing a novel Wharton transposition to access useful quantities of 1,3-disubstituted cubanes for diverse applications.
报道了一种稳健的、毫克至克级规模的 1,3-二取代立方烷的合成方法（此前仅可在毫克级规模获得）。该方法利用了一种易得的烯酮中间体，该中间体之前曾用于 1,4-二取代立方烷的合成，通过引入一种新颖的 Wharton 重排反应，可以获得大量有用的 1,3-二取代立方烷，用于各种应用。
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