立方基酮的拜耳-维利格氧化反应：一种合成官能化古巴醇的路线。
The Baeyer-Villiger Oxidation of Cubyl Ketones: A Synthetic Route to Functionalized Cubanols.
作者信息
Hind Jasmine, Fallis Ian A, Platts James A, Tredwell Matthew
机构信息
School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, U.K.
Wales Research and Diagnostic PET Imaging Centre, Cardiff University, University Hospital of Wales, Heath Park, Cardiff, CF14 4XN, U.K.
出版信息
Org Lett. 2025 Aug 22;27(33):9218-9222. doi: 10.1021/acs.orglett.5c02760. Epub 2025 Aug 8.
The synthesis of functionalized cubanols has been developed via a 2-step protocol comprising of a Baeyer-Villiger oxidation of cubyl ketones, followed by acid hydrolysis. As part of this study, we determine the relative migratory aptitude of cubyl groups in the Baeyer-Villiger oxidation and rationalize these experimental findings with computational studies.
通过包含立方基酮的拜耳-维利格氧化反应，随后进行酸水解的两步方案，已实现了功能化古巴醇的合成。作为本研究的一部分，我们确定了拜耳-维利格氧化反应中立方基团的相对迁移能力，并通过计算研究对这些实验结果进行了合理分析。
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